循环炎性细胞因子可预测 COVID-19 住院患者的病情严重程度：欧洲 DRAGON 联盟的一项前瞻性多中心研究。

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2024-11-06 DOI:10.1016/j.jiph.2024.102589

Barbara Polese , Marie Ernst , Monique Henket , Benoit Ernst , Marie Winandy , Makon-Sébastien Njock , Céline Blockx , Stéphanie Kovacs , Florence Watar , Anna Julie Peired , Sara Tomassetti , Cosimo Nardi , Stéphanie Gofflot , Souad Rahmouni , James PR Schofield , Rebekah Penrice-Randal , Paul J. Skipp , Fabio Strazzeri , Erika Parkinson , Gilles Darcis , Julien Guiot

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引用次数: 0

摘要

背景：COVID-19 给全球医疗系统带来了巨大压力，需要前所未有的重症监护资源。目前，临床上对能够预测严重疾病风险的简易生物标志物的需求仍未得到满足。这项前瞻性多中心研究的主要目的是确定可预测重症监护病房入院和院内死亡率的生物标志物：我们在比利时和意大利的两家医院前瞻性地招募了 COVID-19 PCR 阳性患者。我们在比利时和意大利的两家医院前瞻性地招募了 COVID-19 PCR 阳性患者，并在患者入院时采集了血液样本，利用 Luminex 技术测量了 20 种潜在的生物标记物。通过逻辑回归模型确定了单独或共同与患者疾病严重程度相关的生物标志物：结果：我们的研究表明，循环炎症细胞因子水平的升高与 COVID-19 住院患者的疾病严重程度有关。CXCL10、IL-4、IL-6 和 MCP-1 的值可预测入住 ICU 的风险。IL-6和MCP-1水平的升高还与COVID-19住院患者的住院死亡有关：结论：总之，COVID-19 患者入院时血液中炎症细胞因子的升高和相关性可预测疾病的严重程度，并表明 SARS-CoV-2 感染导致炎症失调。

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Circulating inflammatory cytokines predict severity disease in hospitalized COVID-19 patients: A prospective multicenter study of the European DRAGON consortium

Background

COVID-19 has put a huge strain on the healthcare systems worldwide, requiring unprecedented intensive care resources. There is still an unmet clinical need for easily available biomarkers capable of predicting the risk for severe disease. The main goal of this prospective multicenter study was to identify biomarkers that could predict ICU admission and in-hospital mortality.

Methods

We prospectively recruited COVID-19 PCR positive patients in two hospitals, in Belgium and Italy. Blood samples were collected at hospital admission and 20 potential biomarkers were measured with the Luminex technology. Logistic regression models were performed to identify the biomarkers that, alone or together, were associated with patient disease severity.

Results

Our study demonstrates that elevated levels of circulating inflammatory cytokines were associated with disease severity in COVID-19 hospitalized patients. CXCL10, IL-4, IL-6 and MCP-1 values were predictive of ICU admission. Elevated levels of IL-6 and MCP-1 were also associated with in hospital death in COVID-19 hospitalized patients.

Conclusion

Altogether, elevated and correlated inflammatory cytokines in the blood of COVID-19 patients at hospital admission are predictive of disease severity and suggest a dysregulated inflammation induced by SARS-CoV-2 infection.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.