血液中葡萄糖代谢标记物与循环淋巴细胞特征之间的关联。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2024-11-07 DOI:10.1016/j.clnu.2024.11.004

T. Schmitz, D. Freuer, J. Linseisen, C. Meisinger

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引用次数: 0

摘要

目的：糖尿病的病理生理学尚不完全清楚；最近的研究表明其与免疫学改变密切相关。因此，本研究旨在调查人群中葡萄糖代谢标志物与血液淋巴细胞特征之间的关系：分析基于德国奥格斯堡 MEGA 研究的 219 名非糖尿病参与者的数据，这些参与者是在 2018 年至 2021 年期间招募的。大多数参与者接受了两次不同的检查，时间间隔为 9 个月。两次检查均采集了空腹静脉血样本，并进行了口服葡萄糖耐量试验（OGTT）。使用流式细胞术分析了新鲜血液中的免疫细胞。使用带随机截距的线性混合回归模型分析了空腹血糖水平、口服葡萄糖栓后 2 小时的血糖水平和糖化血红蛋白 (HbA1c) 浓度与不同淋巴细胞亚群数量之间的关系。P值经FDR调整：结果：HbA1c 与边缘区 B 细胞（IgD + CD27+ B 细胞）呈负相关。空腹血糖与自然杀伤（NK）细胞呈正相关，2 小时 OGTT 血糖与 NKT 细胞呈正相关。最后，HbA1c 与 CD57-PD1-NKT 细胞亚群呈显著负相关：结论：糖代谢指标与 B 细胞、NK 细胞和 NKT 细胞亚群有明显的相关性，这清楚地表明了糖代谢与适应性免疫系统之间的关系。

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Associations between blood markers of glucose metabolism and characteristics of circulating lymphocytes

Aims

The pathophysiology of diabetes is not fully understood; recent research indicates close relations with immunological alterations. Therefore, the aim of this study was to investigate the associations between markers of glucose metabolism and characteristics of blood lymphocytes in a population-based cohort.

Methods

The analysis was based on data from 219 non-diabetic participants of the MEGA study in Augsburg, Germany, who were recruited between 2018 and 2021. The majority of participants were examined two different times with a time lag of 9 months. Fasting venous blood samples were taken and oral glucose tolerance tests (OGTT) were performed at both visits. Immune cells were analyzed from fresh blood using flow cytometry. The associations between fasting blood glucose levels, glucose levels at 2 h after oral glucose bolus and glycated hemoglobin (HbA1c) concentrations and the quantity of different lymphocyte subsets were analyzed using linear mixed regression models with random intercept. P values were FDR-adjusted.

Results

HbA1c was negatively associated with the marginal zone B cells (IgD + CD27+ B cells). Fasting glucose was positively associated with natural killer (NK) cells and 2-h OGTT glucose was positively associated with NKT cells. Finally, HbA1c showed significantly negative associations with the CD57-PD1-NKT cell subset.

Conclusion

Markers of glucose metabolism showed significant associations with B cell, NK cell and NKT cell subsets, which clearly indicates a relation between glucose metabolism and the adaptive immune system.

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.