Jingli Zhang, Zengyu Zhang, Mengrui Su, Xingyu Xu, Rongyao Gao, Bingran Yu, Xiaoyu Yan
{"title":"具有内置二级配位层的环甲基化 N-二氟甲基苯并咪唑亚基铂(II)配合物：光物理特性和生物成像。","authors":"Jingli Zhang, Zengyu Zhang, Mengrui Su, Xingyu Xu, Rongyao Gao, Bingran Yu, Xiaoyu Yan","doi":"10.1021/acs.inorgchem.4c03713","DOIUrl":null,"url":null,"abstract":"<p><p>Bidentate Pt(II) complexes with cyclometalated <i>N</i>-heteroarene or <i>N</i>-heterocyclic carbene (NHC) ligands have been extensively studied as phosphorescent emitters over the past two decades. Herein, we introduce a difluoromethyl group (CF<sub>2</sub>H) into the wingtip of NHCs, where CF<sub>2</sub>H acts as a lipophilic hydrogen bond (HB) donor. Their cyclometalated Pt(II) complexes show excellent PLQYs (up to 93%) and phosphorescence lifetimes mainly due to the rigid structure with hydrogen bonding between the CF<sub>2</sub>H group and the adjacent O atom at the β-diketonate ligand. Bioimaging studies demonstrate high cellular uptake efficiency and deep tumor penetration capability of complex <b>7</b> in HeLa cells and multicellular tumor spheroids, highlighting their potential as bioimaging probes.</p>","PeriodicalId":40,"journal":{"name":"Inorganic Chemistry","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cyclometalated <i>N</i>-Difluoromethylbenzimidazolylidene Platinum(II) Complexes with Built-in Secondary Coordination Spheres: Photophysical Properties and Bioimaging.\",\"authors\":\"Jingli Zhang, Zengyu Zhang, Mengrui Su, Xingyu Xu, Rongyao Gao, Bingran Yu, Xiaoyu Yan\",\"doi\":\"10.1021/acs.inorgchem.4c03713\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bidentate Pt(II) complexes with cyclometalated <i>N</i>-heteroarene or <i>N</i>-heterocyclic carbene (NHC) ligands have been extensively studied as phosphorescent emitters over the past two decades. Herein, we introduce a difluoromethyl group (CF<sub>2</sub>H) into the wingtip of NHCs, where CF<sub>2</sub>H acts as a lipophilic hydrogen bond (HB) donor. Their cyclometalated Pt(II) complexes show excellent PLQYs (up to 93%) and phosphorescence lifetimes mainly due to the rigid structure with hydrogen bonding between the CF<sub>2</sub>H group and the adjacent O atom at the β-diketonate ligand. Bioimaging studies demonstrate high cellular uptake efficiency and deep tumor penetration capability of complex <b>7</b> in HeLa cells and multicellular tumor spheroids, highlighting their potential as bioimaging probes.</p>\",\"PeriodicalId\":40,\"journal\":{\"name\":\"Inorganic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.inorgchem.4c03713\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.inorgchem.4c03713","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Cyclometalated N-Difluoromethylbenzimidazolylidene Platinum(II) Complexes with Built-in Secondary Coordination Spheres: Photophysical Properties and Bioimaging.
Bidentate Pt(II) complexes with cyclometalated N-heteroarene or N-heterocyclic carbene (NHC) ligands have been extensively studied as phosphorescent emitters over the past two decades. Herein, we introduce a difluoromethyl group (CF2H) into the wingtip of NHCs, where CF2H acts as a lipophilic hydrogen bond (HB) donor. Their cyclometalated Pt(II) complexes show excellent PLQYs (up to 93%) and phosphorescence lifetimes mainly due to the rigid structure with hydrogen bonding between the CF2H group and the adjacent O atom at the β-diketonate ligand. Bioimaging studies demonstrate high cellular uptake efficiency and deep tumor penetration capability of complex 7 in HeLa cells and multicellular tumor spheroids, highlighting their potential as bioimaging probes.
期刊介绍：
Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.
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