使用有机还原剂，通过镍催化 S-2-吡啶硫酯与氧化还原活性酯之间的偶联获得酮体

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-11-15 DOI:10.1021/acs.joc.4c01242

Jiang-Hong Liu, Ze-Yu Tian, Zhen-Ye Wu, Tian-Le Huang, Zheng Lin, Le Zhang, Jian Chen, Li Hai, Li Guo, Yong Wu

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引用次数: 0

摘要

有报道称，S-2-吡啶硫代酯与氧化还原活性酯之间存在镍催化偶联。在这一策略中，二鲁丁被用作还原剂。我们的方法能以中等至良好的收率快速获得目标酮产品。通过这种方法还实现了非异构 C-酰基苷的构建。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Access to Ketones via Nickel-Catalyzed Coupling between S-2-Pyridyl Thioesters and Redox-Active Esters Using an Organic Reductant

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Access to Ketones via Nickel-Catalyzed Coupling between S-2-Pyridyl Thioesters and Redox-Active Esters Using an Organic Reductant

A nickel-catalyzed coupling between S-2-pyridyl thioesters and redox-active esters has been reported. Diludine was used as a reductant in this strategy. Our method rapidly achieves the target ketone products in moderate to good yield. The construction of nonanomeric C-acyl glycosides was realized through the approach as well.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.