实用、大规模制备 Ni(tmeda)(邻甲苯)Cl

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2024-11-15 DOI:10.1021/acs.oprd.4c00408

Morgan E. John, Daven Foster, Stephen A. Moggach, George A. Koutsantonis, Reto Dorta, Scott G. Stewart

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引用次数: 0

摘要

本文介绍了一种方便、廉价的合成方法，可以合成之前报道过的定义明确的络合物 Ni(tmeda)(邻-tol)Cl。这种方法可以快速安全地获得 Ni(tmeda)(邻甲苯)Cl，避免了使用危险试剂 AlMe3 或对空气敏感的 Ni(COD)2。Ni(tmeda)(o-tol)Cl 是在室温下从市场上容易合成的前体 Ni(acac)2 中制备出来的，通过简单的过滤就能在空气中分离出克级的 Ni(tmeda)(o-tol)Cl。考虑到所使用的溶剂类型、反应温度和试剂，我们预计这种简单的方法将对化学工业和学术界具有吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Practical, Large-Scale Preparation of Ni(tmeda)(o-tol)Cl

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Practical, Large-Scale Preparation of Ni(tmeda)(o-tol)Cl

A convenient, inexpensive synthesis of the previously reported, well-defined complex Ni(tmeda)(o-tol)Cl is described. This protocol enables rapid and safe access to Ni(tmeda)(o-tol)Cl, obviating the use of the hazardous reagent AlMe₃ or air-sensitive Ni(COD)₂. Ni(tmeda)(o-tol)Cl is prepared at room temperature from commercially available and easily synthesized precursor Ni(acac)₂ and can be isolated at gram scale in air via simple filtration. We expect this simple method to be attractive to chemical industry and academia given the types of solvents, reaction temperature, and reagents used.

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.