通过分子内交叉安息香反应荧光检测纯水介质中的氰离子:揭示的局限性和可能的解决方案

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL
Analyst Pub Date : 2024-11-15 DOI:10.1039/D4AN01368A
Vincent Gaumerd, Yoan Capello, Quentin Bonnin, Pierre-Yves Renard and Anthony Romieu
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引用次数: 0

摘要

对水基质中致命的氰阴离子进行基于反应的荧光传感仍然是一个巨大的挑战。我们重新研究了已报道的分子内交叉安息香反应导致苯酚基荧光团释放的方法。荧光测定和 RP-HPLC-MS 分析帮助我们强调了该方法的局限性,即探针的水稳定性差,以及尽管假定了催化活化机制,但却无法实现分子放大。我们考虑了无痕可裂解链接策略,以获得可用的氰化物响应化学剂量计,并深化了荧光数据的统计分析,以准确界定其传感性能,尤其是检测限(LOD)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fluorogenic detection of cyanide ions in pure aqueous media through an intramolecular crossed-benzoin reaction: limitations unveiled and possible solutions†‡

Fluorogenic detection of cyanide ions in pure aqueous media through an intramolecular crossed-benzoin reaction: limitations unveiled and possible solutions†‡

Reaction-based fluorogenic sensing of lethal cyanide anions in aqueous matrices remains a big challenge. We have revisited the reported approach about an intramolecular crossed-benzoin reaction leading to the release of a phenol-based fluorophore. Fluorescence assays and RP-HPLC-MS analyses have helped us to highlight its limitations related to poor aqueous stability of probes and impossibility to achieve molecular amplification despite the assumed catalytic activation mechanism. Traceless cleavable linker strategies were considered to obtain usable cyanide-responsive chemodosimeters and statistical analyses of fluorescence data have been conducted in depth to accurately delineate their sensing performances, especially the limit of detection (LOD).

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来源期刊
Analyst
Analyst 化学-分析化学
CiteScore
7.80
自引率
4.80%
发文量
636
审稿时长
1.9 months
期刊介绍: "Analyst" journal is the home of premier fundamental discoveries, inventions and applications in the analytical and bioanalytical sciences.
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