制备可在水中分散的 Perovskite 量子点用于生物医学应用

IF 2.9 4区 工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY
Sang Bin Yoon, Sukyeong Hwang, Yerin Kim, Bong-Geun Kim, Hyon Bin Na
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引用次数: 0

摘要

这篇综述重点介绍了在生物医学应用中稳定光致发光量子点(PQDs)方面的最新进展。CsPbBr3 纳米粒子等 PQDs 具有很高的光致发光量子产率、较窄的发射线宽以及控制激发和发射波长的能力,因此非常适合生物成像和传感应用。然而,它们在潮湿和水环境中的不稳定性以及铅等重金属的潜在毒性带来了巨大挑战。为了解决这些问题,人们开发了各种表面修饰策略,包括封装、配体交换和相转移。这些方法旨在提高 PQD 的稳定性和生物相容性,同时保留其光学特性。使用聚合物、二氧化硅和磷脂的封装技术在保持 PQD 在水溶液中的稳定性方面大有可为。使用多叉配体和多功能配体的配体交换策略增强了 PQD 的表面结合力和亲水性,提高了它们在环境中的稳健性。荧光细胞成像、温度检测和免疫测定等应用证明了稳定 PQDs 在生物医学应用中的潜力。尽管取得了这些进展,但要开发出无毒的 PQD 并确保其长期稳定性,还需要进一步的研究。PQD 合成和表面修饰技术的不断进步将为生物医学研究和临床诊断带来重大突破。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation of Water-Dispersible Perovskite-Quantum Dots for Biomedical Applications

This review highlights recent advancements in stabilizing perovskite-quantum dots (PQDs) for biomedical applications. PQDs like CsPbBr3 nanoparticles are promising due to their high photoluminescence-quantum yield, narrow emission linewidth, and ability to control excitation and emission wavelengths, making them suitable for bioimaging and sensing applications. However, their instability in moist and aqueous environments and potential toxicity due to heavy metals like lead pose significant challenges. To address these issues, various surface-modification strategies, including encapsulation, ligand exchange, and phase transfer, have been developed. These methods aim to improve PQD stability and biocompatibility while preserving their optical properties. Encapsulation techniques using polymers, silica, and phospholipids have shown promise in maintaining PQD stability in aqueous solutions. Ligand-exchange strategies with multidentate and multifunctional ligands have enhanced PQD surface binding and hydrophilicity, improving their environmental robustness. Applications such as fluorescence cellular imaging, theragnostics, and immunoassays demonstrate the potential of stabilized PQDs in biomedical applications. Despite these advancements, further research is needed to develop non-toxic PQDs and ensure long-term stability. Continued progress in PQD synthesis and surface modification could lead to significant breakthroughs in biomedical research and clinical diagnostics.

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来源期刊
Korean Journal of Chemical Engineering
Korean Journal of Chemical Engineering 工程技术-工程:化工
CiteScore
4.60
自引率
11.10%
发文量
310
审稿时长
4.7 months
期刊介绍: The Korean Journal of Chemical Engineering provides a global forum for the dissemination of research in chemical engineering. The Journal publishes significant research results obtained in the Asia-Pacific region, and simultaneously introduces recent technical progress made in other areas of the world to this region. Submitted research papers must be of potential industrial significance and specifically concerned with chemical engineering. The editors will give preference to papers having a clearly stated practical scope and applicability in the areas of chemical engineering, and to those where new theoretical concepts are supported by new experimental details. The Journal also regularly publishes featured reviews on emerging and industrially important subjects of chemical engineering as well as selected papers presented at international conferences on the subjects.
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