酮的机械化学二氟甲基化反应。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.235

Jinbo Ke, Pit van Bonn, Carsten Bolm

引用次数: 0

摘要

我们介绍了一种二氟甲基烯醇醚的机械化学合成方法。利用二氟烯烃的原位生成，酮在无溶剂条件下高效地转化为目标产物。反应在室温下进行，90 分钟内完成，既高效又简单。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanochemical difluoromethylations of ketones.

We present a mechanochemical synthesis of difluoromethyl enol ethers. Utilizing an in situ generation of difluorocarbenes, ketones are efficiently converted to the target products under solvent-free conditions. The reactions proceed at room temperature and are complete within 90 minutes, demonstrating both efficiency and experimental simplicity.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.