接种伤寒疫苗后出现致命的上升性麻痹：吉兰（Guillain）和巴雷（Barré）对首例病例的描述。

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2024-11-12 DOI:10.1016/j.vaccine.2024.126443

Eelco F.M. Wijdicks

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引用次数: 0

摘要

背景：尽管罕见，但吉兰-巴雷综合征（GBS）与多种疫苗有关。有关这些关联的调查在 1950 年以前从未见过。在此，我重温了第一例描述的疫苗相关吉-巴氏综合征病例，该病例出现在大战期间，当时是为了预防伤寒：方法：回顾原始和二手资料。描述一个具有里程碑意义的病例：回顾一名 31 岁准将的报告，他重新接种了 "vaccin TAB"（A 型和 B 型三联抗伤寒-副伤寒疫苗），几天后出现四肢无力、口咽无力和致命性神经肌肉呼吸无力的快速发展。脑脊液显示轻度多细胞和蛋白（白蛋白）增加。尸检结果显示大脑和脊髓正常：这是首例报告的疫苗相关性 GBS 病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fatal ascending paralysis after typhoid vaccine: Guillain and Barré's description of the very first case

Background: Albeit rare, Guillain - Barré syndrome (GBS) has been associated with several vaccines. Surveys of these associations have not looked before 1950. Herein, I revisit the first described case of vaccine-associated GBS, manifesting during the Great War and to prevent typhoid.

Methods: Review of primary and secondary source material. Description of a landmark case.

Results: Review of a report of a 31-year-old brigadier who was revaccinated with “vaccin TAB” (a triple antityphoid-paratyphoid vaccine A and B) which days later was followed by rapid progression of limb weakness, oropharyngeal weakness and fatal neuromuscular respiratory weakness. Cerebrospinal fluid showed mild pleocytosis and increased protein (albumen). There was a normal brain and spinal cord at autopsy.

Conclusion: This is the first reported case of a vaccine-associated GBS.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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