使用 Haemonetics MCS+ 和 Trima Accel 系统进行单次和两次血小板球沉手术中血液参数和仪器性能的比较评估。

IF 1.4 4区医学 Q4 HEMATOLOGY

Transfusion Clinique et Biologique Pub Date : 2025-02-01 DOI:10.1016/j.tracli.2024.11.002

Niloufar Kazemi Babaahmadi , Maryam Kheirandish , Amir Teimourpour , Saeed Mohammadi , Amir Masoud Nazemi

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引用次数: 0

摘要

目的：血小板球蛋白（Plateletpheresis，PP）因其成本效益高、受者免疫和感染并发症少而日益盛行。本研究比较了血小板捐献者的血液学指标以及使用 Haemonetics MCS+ 和 Trima Accel 的高产 PP 献血者的仪器相关参数：19名单剂量血小板（SDP）和26名双剂量血小板（DDP）捐献者使用Haemonetics MCS+进行了血小板捐献，21名单剂量血小板和21名双剂量血小板捐献者使用Trima Accel系统进行了血小板捐献。使用细胞计数器测量了两组供体的全血细胞计数（CBC）和血液指标。对两种设备的血小板产量、采集效率（CE）和采集率（CR）进行了评估。结果使用 R-4.3.2 软件和 p 值报告：双剂量血小板球塞术（DDP）在成本效益和血小板产量方面具有优势，虽然它降低了一些血液学指标，但这些指标仍在正常范围内。与 MCS+ 相比，Trima Accel 可提供更高的效率和更短的处理时间。不过，按照 AABB 标准对 DDP 供血者进行仔细监测仍然至关重要。

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Comparative evaluation of hematological parameters and instrument performance in single and double plateletpheresis procedures using Haemonetics MCS+ and Trima Accel systems

Objectives

Plateletpheresis (PP) has become increasingly prevalent due to its cost-effectiveness and fewer immunological and infectious complications for recipients. This study compares hematological indices of platelet donors and instrument-related parameters in high-yield PP donors using Haemonetics MCS+ and Trima Accel.

Methods

Eligible and healthy PP donors meeting the platelet donation criteria were randomly selected.19 single-dose platelet (SDP), and 26 double-dose platelet (DDP) donors underwent PP using the Haemonetics MCS+, while 21 SDP and 21 DDP donors were processed using the Trima Accel system. Complete Blood Count (CBC) and hematological indices of donors between groups with both devices were measured with the cell counter. Platelet yield, collection efficiency (CE), and collection rate (CR) were evaluated for both devices. Results were reported using R-4.3.2 software and a p-value <0.05 was considered statistically significant.

Results

The Trima Accel processed significantly more blood volume and had shorter procedure times than MCS+. Platelet yield in the SDP group with Trima Accel was significantly higher than the Haemonetics MCS+. The Trima Accel demonstrated a significantly higher CR and CE than the MCS+ in both SDP and DDP groups. Post-PP lymphocyte counts significantly decreased with the Trima compared to the MCS+ in the SDP group. However, post-PP hematocrit (HCT), mean corpuscular volume (MCV), and mean platelet volume (MPV) in the DDP group with the MCS+ were significantly lower than Trima.

Conclusion

Double-dose plateletpheresis (DDP) offers advantages in cost-effectiveness and platelet production, and although it reduces some hematological indices, these remain within normal limits. The Trima Accel may offer superior efficiency and processing times compared to the MCS+. However, careful monitoring of DDP donors following AABB standards remains essential.

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来源期刊

Transfusion Clinique et Biologique 医学-免疫学

CiteScore

2.50

自引率

11.80%

发文量

234

审稿时长

36 days

期刊介绍： Transfusion Clinique et Biologique, the official journal of the French Society of Blood Transfusion (SFTS): - an aid to training, at a European level - the only French journal indexed in the hematology and immunology sections of Current Contents Transfusion Clinique et Biologique spans fundamental research and everyday practice, with articles coming from both sides. Articles, reviews, case reports, letters to the editor and editorials are published in 4 editions a year, in French or in English, covering all scientific and medical aspects of transfusion: immunology, hematology, infectious diseases, genetics, molecular biology, etc. And finally, a convivial cross-disciplinary section on training and information offers practical updates. Readership: "Transfusers" are many and various: anesthetists, biologists, hematologists, and blood-bank, ICU and mobile emergency specialists...