oct 血管造影值的变化预测青光眼进展期患者视野和视网膜神经层断层成像进展的能力：前瞻性研究。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2024-11-12 DOI:10.1016/j.pdpdt.2024.104382

Suleyman Demir, Mehmet Talay Koylu, Alper Can Yılmaz

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引用次数: 0

摘要

导言：研究光学相干断层血管造影（OCTA）值的变化能否预测青光眼进展期患者视野（VF）和视网膜神经纤维层（RNFL）的进展：2021年至2023年期间在SBU Gulhane医学院青光眼门诊就诊的所有患者均接受了RNFL、24:2 VF和同时进行的毛细血管周围OCTA检查。研究共纳入了 130 只眼球。在 6 个月内，任何象限的 RNFL 变薄超过 5 μ 或视野 MD 值下降超过 1 dB 即为病情进展标准。前瞻性研究了 OCTA 厚度值的变化和 OCTA 径向毛细血管周围丛（RPCP）分析预测 RNFL 和 VF 进展的能力：患者的平均年龄为（66.9 ± 11.8）岁。从基线值到 6 个月的对照值之间，70 只眼睛的 VF 和 89 只眼睛的 RNFL 出现了进展。OCTA 厚度值的变化不足以预测上象限、下象限、鼻象限、颞象限和总象限的 RNFL 进展情况（p = 0.55、0.40、0.84、0.91、0.39）。OCTA 厚度值的变化不能预测上象限、下象限、鼻象限、颞象限和总象限的 VF MD 进展（p = 0.40、0.11、0.24、0.44、0.10）。OCTA RPCP 值的变化在预测上象限、下象限、鼻象限、颞象限和总象限的 RNFL 进展方面没有显示出优越性（p = 0.21、0.53、0.39、0.39、0.29，分别为 0.21、0.53、0.39、0.39、0.29）。在预测上象限、下象限、鼻象限、颞象限和总象限的 VF 进展方面，OCTA RPCP 值的变化并未显示出优越性（p = 0.96、0.29、0.77、0.42、0.21）：尽管 OCTA 是一种无创成像检测方法，近年来其使用和普及率不断提高，但我们的研究并未显示其在显示青光眼进展方面优于 RNFL 和 VF 检测方法。

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The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study

Introduction

To investigate whether changes in optical coherence tomography angiography (OCTA) values can predict progression in the visual field (VF) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression.

Methods

All patients in the glaucoma outpatient clinic of SBU Gulhane Medicine Faculty between 2021 and 2023 underwent RNFL, 24:2 VF, and simultaneous peripapillary OCTA. 130 eyes that progressed were included in the study. Thinning of more than 5 μ in any quadrant in the RNFL or a decrease of more than 1 dB in the MD value in the visual field within 6 months was accepted as a progression criterion. The ability of changes in OCTA thickness values and OCTA radial peripapillary capillary plexus (RPCP) analysis to predict progression in RNFL and VF was prospectively investigated.

Results

The mean age of the patients was 66.9 ± 11.8 years. There was progression in VF in 70 eyes and RNFL in 89 eyes between baseline and 6-month controls. The change in OCTA thickness values had insufficient ability to predict the progression of RNFL in the superior, inferior, nasal, temporal and total quadrants (p = 0.55, 0.40, 0.84, 0.91, 0.39, respectively). The changes in OCTA thickness values failed to predict VF MD progression in the superior, inferior,nasal,temporal,and total quadrants (p = 0.40, 0.11, 0.24, 0.44, 0.10, respectively). The changes in OCTA RPCP values did not show superiority in the ability to predict RNFL progression in superior, inferior, nasal, temporal, and total quadrants (p = 0.21, 0.53, 0.39, 0.39, 0.29, respectively). The changes in OCTA RPCP values did not show superiority in the ability to predict VF progression in superior, inferior, nasal, temporal, and total quadrants (p = 0.96, 0.29, 0.77, 0.42, 0.21, respectively).

Conclusion

Although OCTA is a non-invasive imaging test whose use and popularity have been increasing in recent years, our study could not show superiority compared to RNFL and VF tests in demonstrating glaucoma progression.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.