癌症中的线粒体 RNA 甲基化。

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI:10.1016/j.bbcan.2024.189213

Luyi Tan , Chenyu Zhu , Xinyu Zhang , Jiaqi Fu , Tingting Huang , Wenji Zhang , Wenjuan Zhang

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引用次数: 0

摘要

线粒体拥有完整而独立的遗传系统，是癌症发生和持续存在的必要生物能源。线粒体 RNA（mt-RNA）甲基化是表观遗传学的一个前沿领域，越来越多的证据表明它与癌症进展有关。本综述从 mt-RNA 甲基化位点、生物学意义及其甲基转移酶等方面全面总结了 mt-RNA 甲基化在调控癌症增殖、转移和免疫渗透方面的详细机制。mt-RNA 甲基化还通过细胞核和线粒体之间的表观遗传学串扰发挥着非常重要的作用。重要的是，研究还分析了 mt-RNA 甲基转移酶的独特结构和功能特征，以及潜在的癌症靶向治疗药物。揭示人类 mt-RNA 甲基化调控系统及其与癌症的关系，将有助于确定潜在的生物标志物和治疗靶点，从而在未来精确预防、检测、干预和治疗癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mitochondrial RNA methylation in cancer

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Mitochondrial RNA methylation in cancer

Mitochondria have a complete and independent genetic system with necessary biological energy for cancer occurrence and persistence. Mitochondrial RNA (mt-RNA) methylation, as a frontier in epigenetics, has linked to cancer progression with growing evidences. This review has comprehensively summarized detailed mechanisms of mt-RNA methylation in regulating cancer proliferation, metastasis, and immune infiltration from the mt-RNA methylation sites, biological significance, and its methyltransferases. The mt-RNA methylation also plays a very significant role via epigenetic crosstalk between nucleus and mitochondria. Importantly, the unique structures and functional characteristics of mt-RNA methyltransferases and the potential targeting treatment drugs for cancer are also analyzed. Revealing human mt-RNA methylation regulatory system and the relationship with cancer will contribute to identifying potential biomarkers and therapeutic targets for precise prevention, detection, intervention and treatment in the future.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.