Zhaolin Hua , Dechuang Zhang , Lin Guo , Sihan Lin , Yuncang Li , Cuie Wen
{"title":"通过旋光分解获得低磁感应强度、高屈服强度和低弹性模量的中熵 Zr-Nb-Ti 合金,用于骨植入应用。","authors":"Zhaolin Hua , Dechuang Zhang , Lin Guo , Sihan Lin , Yuncang Li , Cuie Wen","doi":"10.1016/j.actbio.2024.11.001","DOIUrl":null,"url":null,"abstract":"<div><div>Medium-entropy Zr–Nb–Ti (ZNT) alloys are being extensively investigated as load-bearing implant materials because of their exceptional biocompatibility and corrosion resistance, and low magnetic susceptibility. Nevertheless, enhancing their yield strength while simultaneously decreasing their elastic modulus presents a formidable obstacle, significantly constraining their broader utilization as metallic biomaterials. In this study, three medium-entropy ZNT alloys, i.e., Zr<sub>45</sub>Nb<sub>45</sub>Ti<sub>10</sub>, Zr<sub>42.5</sub>Nb<sub>42.5</sub>Ti<sub>15</sub>, and Zr<sub>40</sub>Nb<sub>40</sub>Ti<sub>20</sub> (denoted ZNT<sub>10</sub>, ZNT<sub>15</sub>, and ZNT<sub>20</sub>, respectively), were designed based on the miscibility gap in the ZNT phase diagram and prepared by annealing of cold-rolled ingots. Their microstructures, mechanical properties, wear resistance, corrosion resistance, magnetic susceptibility, and biocompatibility were systematically studied. Spinodal decomposition occurred in the cold-rolled ZNT<sub>10</sub> and ZNTi<sub>15</sub> after annealing at 650 °C for 2 h and resulted in nanoscale Zr-rich β<sub>1</sub> and (Nb, Ti)-rich β<sub>2</sub> phases, which significantly improved their yield strength and reduced their elastic modulus. The wear resistance of the alloys decreased with an increase in Ti content. Dense ZrO<sub>2</sub>, Nb<sub>2</sub>O<sub>5</sub>, and TiO<sub>2</sub> oxide layers were formed during the polarization process in Hanks’ solution, which enhanced the corrosion resistance of the alloys. These ZNT alloys exhibited significantly lower magnetic susceptibility than medical Ti alloys. The ZNT alloys showed a cell viability of more than 94 % toward MG-63 cells after culturing for 3 d Overall, the spinodal ZNT<sub>15</sub> showed the best combination of mechanical properties, wear resistance, corrosion resistance, low magnetic susceptibility, and sufficient biocompatibility among the three alloys.</div></div><div><h3>Statement of significance</h3><div>This work reports on medium-entropy Zr–Nb–Ti (ZNT) alloys with heterostructure. Spinodal decomposition significantly improved their mechanical strength and reduced the elastic modulus of the alloys. The wear resistance of the ZNT alloys decreased with an increase in Ti content. Dense ZrO<sub>2</sub>, Nb<sub>2</sub>O<sub>5</sub>, and TiO<sub>2</sub> oxide layers were formed during the polarization process in Hanks’ solution, which enhanced the corrosion resistance of the alloys. The ZNT alloys exhibited significantly lower magnetic susceptibility than medical Ti alloys. The ZNT alloys showed a cell viability of >94 % toward MG-63 cells after culturing for 3 d The results demonstrate that spinodal ZNT alloys have enormous potential as bone-implant materials due to their outstanding overall mechanical properties, high corrosion resistance, wear resistance, low magnetic susceptibility, and sufficient biocompatibility.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"190 ","pages":"Pages 623-641"},"PeriodicalIF":9.4000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Medium-entropy Zr–Nb–Ti alloys with low magnetic susceptibility, high yield strength, and low elastic modulus through spinodal decomposition for bone-implant applications\",\"authors\":\"Zhaolin Hua , Dechuang Zhang , Lin Guo , Sihan Lin , Yuncang Li , Cuie Wen\",\"doi\":\"10.1016/j.actbio.2024.11.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Medium-entropy Zr–Nb–Ti (ZNT) alloys are being extensively investigated as load-bearing implant materials because of their exceptional biocompatibility and corrosion resistance, and low magnetic susceptibility. Nevertheless, enhancing their yield strength while simultaneously decreasing their elastic modulus presents a formidable obstacle, significantly constraining their broader utilization as metallic biomaterials. In this study, three medium-entropy ZNT alloys, i.e., Zr<sub>45</sub>Nb<sub>45</sub>Ti<sub>10</sub>, Zr<sub>42.5</sub>Nb<sub>42.5</sub>Ti<sub>15</sub>, and Zr<sub>40</sub>Nb<sub>40</sub>Ti<sub>20</sub> (denoted ZNT<sub>10</sub>, ZNT<sub>15</sub>, and ZNT<sub>20</sub>, respectively), were designed based on the miscibility gap in the ZNT phase diagram and prepared by annealing of cold-rolled ingots. Their microstructures, mechanical properties, wear resistance, corrosion resistance, magnetic susceptibility, and biocompatibility were systematically studied. Spinodal decomposition occurred in the cold-rolled ZNT<sub>10</sub> and ZNTi<sub>15</sub> after annealing at 650 °C for 2 h and resulted in nanoscale Zr-rich β<sub>1</sub> and (Nb, Ti)-rich β<sub>2</sub> phases, which significantly improved their yield strength and reduced their elastic modulus. The wear resistance of the alloys decreased with an increase in Ti content. Dense ZrO<sub>2</sub>, Nb<sub>2</sub>O<sub>5</sub>, and TiO<sub>2</sub> oxide layers were formed during the polarization process in Hanks’ solution, which enhanced the corrosion resistance of the alloys. These ZNT alloys exhibited significantly lower magnetic susceptibility than medical Ti alloys. The ZNT alloys showed a cell viability of more than 94 % toward MG-63 cells after culturing for 3 d Overall, the spinodal ZNT<sub>15</sub> showed the best combination of mechanical properties, wear resistance, corrosion resistance, low magnetic susceptibility, and sufficient biocompatibility among the three alloys.</div></div><div><h3>Statement of significance</h3><div>This work reports on medium-entropy Zr–Nb–Ti (ZNT) alloys with heterostructure. Spinodal decomposition significantly improved their mechanical strength and reduced the elastic modulus of the alloys. The wear resistance of the ZNT alloys decreased with an increase in Ti content. Dense ZrO<sub>2</sub>, Nb<sub>2</sub>O<sub>5</sub>, and TiO<sub>2</sub> oxide layers were formed during the polarization process in Hanks’ solution, which enhanced the corrosion resistance of the alloys. The ZNT alloys exhibited significantly lower magnetic susceptibility than medical Ti alloys. The ZNT alloys showed a cell viability of >94 % toward MG-63 cells after culturing for 3 d The results demonstrate that spinodal ZNT alloys have enormous potential as bone-implant materials due to their outstanding overall mechanical properties, high corrosion resistance, wear resistance, low magnetic susceptibility, and sufficient biocompatibility.</div></div>\",\"PeriodicalId\":237,\"journal\":{\"name\":\"Acta Biomaterialia\",\"volume\":\"190 \",\"pages\":\"Pages 623-641\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Biomaterialia\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1742706124006445\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Biomaterialia","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1742706124006445","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Medium-entropy Zr–Nb–Ti alloys with low magnetic susceptibility, high yield strength, and low elastic modulus through spinodal decomposition for bone-implant applications
Medium-entropy Zr–Nb–Ti (ZNT) alloys are being extensively investigated as load-bearing implant materials because of their exceptional biocompatibility and corrosion resistance, and low magnetic susceptibility. Nevertheless, enhancing their yield strength while simultaneously decreasing their elastic modulus presents a formidable obstacle, significantly constraining their broader utilization as metallic biomaterials. In this study, three medium-entropy ZNT alloys, i.e., Zr45Nb45Ti10, Zr42.5Nb42.5Ti15, and Zr40Nb40Ti20 (denoted ZNT10, ZNT15, and ZNT20, respectively), were designed based on the miscibility gap in the ZNT phase diagram and prepared by annealing of cold-rolled ingots. Their microstructures, mechanical properties, wear resistance, corrosion resistance, magnetic susceptibility, and biocompatibility were systematically studied. Spinodal decomposition occurred in the cold-rolled ZNT10 and ZNTi15 after annealing at 650 °C for 2 h and resulted in nanoscale Zr-rich β1 and (Nb, Ti)-rich β2 phases, which significantly improved their yield strength and reduced their elastic modulus. The wear resistance of the alloys decreased with an increase in Ti content. Dense ZrO2, Nb2O5, and TiO2 oxide layers were formed during the polarization process in Hanks’ solution, which enhanced the corrosion resistance of the alloys. These ZNT alloys exhibited significantly lower magnetic susceptibility than medical Ti alloys. The ZNT alloys showed a cell viability of more than 94 % toward MG-63 cells after culturing for 3 d Overall, the spinodal ZNT15 showed the best combination of mechanical properties, wear resistance, corrosion resistance, low magnetic susceptibility, and sufficient biocompatibility among the three alloys.
Statement of significance
This work reports on medium-entropy Zr–Nb–Ti (ZNT) alloys with heterostructure. Spinodal decomposition significantly improved their mechanical strength and reduced the elastic modulus of the alloys. The wear resistance of the ZNT alloys decreased with an increase in Ti content. Dense ZrO2, Nb2O5, and TiO2 oxide layers were formed during the polarization process in Hanks’ solution, which enhanced the corrosion resistance of the alloys. The ZNT alloys exhibited significantly lower magnetic susceptibility than medical Ti alloys. The ZNT alloys showed a cell viability of >94 % toward MG-63 cells after culturing for 3 d The results demonstrate that spinodal ZNT alloys have enormous potential as bone-implant materials due to their outstanding overall mechanical properties, high corrosion resistance, wear resistance, low magnetic susceptibility, and sufficient biocompatibility.
期刊介绍:
Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.