生物可降解 Mg-Y-Nd-Zr 合金热处理在临床中的应用:揭示β'和β1纳米相的作用以及体内潜在的氢演化。

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Matthew Dargusch , Yuan Wang , Chuhan Sha , Nan Yang , Xingrui Chen , Jeffrey Venezuela , Joseph Otte , Sean Johnston , Cora Lau , Rachel Allavena , Karine Mardon , Ingrid McCaroll , Julie Cairney
{"title":"生物可降解 Mg-Y-Nd-Zr 合金热处理在临床中的应用:揭示β'和β1纳米相的作用以及体内潜在的氢演化。","authors":"Matthew Dargusch ,&nbsp;Yuan Wang ,&nbsp;Chuhan Sha ,&nbsp;Nan Yang ,&nbsp;Xingrui Chen ,&nbsp;Jeffrey Venezuela ,&nbsp;Joseph Otte ,&nbsp;Sean Johnston ,&nbsp;Cora Lau ,&nbsp;Rachel Allavena ,&nbsp;Karine Mardon ,&nbsp;Ingrid McCaroll ,&nbsp;Julie Cairney","doi":"10.1016/j.actbio.2024.10.047","DOIUrl":null,"url":null,"abstract":"<div><div>Heat treatment serves as a viable strategy to effectively mitigate the intense corrosion of biodegradable WE43 alloys. However, limited comprehension of the passivation mechanisms underlying heat treatment and the dilemma to quantitatively examine the evolution of hydrogen gas <em>in vivo</em> introduce uncertainties in designing heat treatments for developing clinically applicable WE43. This work aims to advance this knowledge by applying cutting-edge atom probe tomography to provide atomic-scale insights into the passivation roles of rare earth (RE)-rich β<sub>1</sub> (Mg<sub>3</sub>(Y, Nd)) and β' (Mg<sub>12</sub>NdY) nanophases induced by T6 heat treatment at 250 °C, and employing machine learning-based image analysis techniques to quantitatively unveil WE43’s <em>in vivo</em> gas evolution during a 12-week implantation. It was found that nanosized β<sub>1</sub> and β' phases can effectively improve WE43′s corrosion resistance by inducing an accelerated passivation effect on the surface and confining the distribution of hydrogen ions in the matrix. Female rats presented slightly higher corrosion rates than male rats in weeks 1 and 4 but lower hydrogen gas volumes <em>in vivo</em>, while male rats possessed a superior ability to metabolise hydrogen gas <em>in vivo</em>. Notably, latent gas evolution against the corrosion rates was found which peaked at week 4 and subsided at week 12 despite the gradually decreased corrosion rates from week 1 to 12. This study offers insights for engineering heat treatments to develop clinically applicable WE43 with acceptable corrosion rates and <em>in vivo</em> gas generation at various implantation stages.</div></div><div><h3>Statement of Significance</h3><div>The study aimed to reveal the role of β<sub>1</sub> and β' nanophases on the good corrosion resistance of WE43. The influence of these nanophases on WE43′s corrosion performance has not been totally understood. Similarly, the understanding of hydrogen gas evolution as it relates to the magnesium implant's corrosion rate lacks clarity. Atom probe tomography (APT) indicates β<sub>1</sub> and β' nanophases trap hydrogen, removing H<sub>2</sub> from the lattice and disabling its catalytic role in Mg oxidation. Machine learning-aided analyses of computed tomography (CT) scan images indicate latent gas evolution, contradicting the monotonic <em>in vivo</em> H<sub>2</sub> evolution that is widely accepted.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"190 ","pages":"Pages 605-622"},"PeriodicalIF":9.4000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Insights into heat treatments of biodegradable Mg-Y-Nd-Zr alloys in clinical settings: Unveiling roles of β' and β1 nanophases and latent in vivo hydrogen evolution\",\"authors\":\"Matthew Dargusch ,&nbsp;Yuan Wang ,&nbsp;Chuhan Sha ,&nbsp;Nan Yang ,&nbsp;Xingrui Chen ,&nbsp;Jeffrey Venezuela ,&nbsp;Joseph Otte ,&nbsp;Sean Johnston ,&nbsp;Cora Lau ,&nbsp;Rachel Allavena ,&nbsp;Karine Mardon ,&nbsp;Ingrid McCaroll ,&nbsp;Julie Cairney\",\"doi\":\"10.1016/j.actbio.2024.10.047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Heat treatment serves as a viable strategy to effectively mitigate the intense corrosion of biodegradable WE43 alloys. However, limited comprehension of the passivation mechanisms underlying heat treatment and the dilemma to quantitatively examine the evolution of hydrogen gas <em>in vivo</em> introduce uncertainties in designing heat treatments for developing clinically applicable WE43. This work aims to advance this knowledge by applying cutting-edge atom probe tomography to provide atomic-scale insights into the passivation roles of rare earth (RE)-rich β<sub>1</sub> (Mg<sub>3</sub>(Y, Nd)) and β' (Mg<sub>12</sub>NdY) nanophases induced by T6 heat treatment at 250 °C, and employing machine learning-based image analysis techniques to quantitatively unveil WE43’s <em>in vivo</em> gas evolution during a 12-week implantation. It was found that nanosized β<sub>1</sub> and β' phases can effectively improve WE43′s corrosion resistance by inducing an accelerated passivation effect on the surface and confining the distribution of hydrogen ions in the matrix. Female rats presented slightly higher corrosion rates than male rats in weeks 1 and 4 but lower hydrogen gas volumes <em>in vivo</em>, while male rats possessed a superior ability to metabolise hydrogen gas <em>in vivo</em>. Notably, latent gas evolution against the corrosion rates was found which peaked at week 4 and subsided at week 12 despite the gradually decreased corrosion rates from week 1 to 12. This study offers insights for engineering heat treatments to develop clinically applicable WE43 with acceptable corrosion rates and <em>in vivo</em> gas generation at various implantation stages.</div></div><div><h3>Statement of Significance</h3><div>The study aimed to reveal the role of β<sub>1</sub> and β' nanophases on the good corrosion resistance of WE43. The influence of these nanophases on WE43′s corrosion performance has not been totally understood. Similarly, the understanding of hydrogen gas evolution as it relates to the magnesium implant's corrosion rate lacks clarity. Atom probe tomography (APT) indicates β<sub>1</sub> and β' nanophases trap hydrogen, removing H<sub>2</sub> from the lattice and disabling its catalytic role in Mg oxidation. Machine learning-aided analyses of computed tomography (CT) scan images indicate latent gas evolution, contradicting the monotonic <em>in vivo</em> H<sub>2</sub> evolution that is widely accepted.</div></div>\",\"PeriodicalId\":237,\"journal\":{\"name\":\"Acta Biomaterialia\",\"volume\":\"190 \",\"pages\":\"Pages 605-622\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Biomaterialia\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1742706124006391\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Biomaterialia","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1742706124006391","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

摘要

热处理是有效缓解可生物降解 WE43 合金强烈腐蚀的可行策略。然而,由于对热处理背后的钝化机制了解有限,以及难以定量检测体内氢气的演变情况,因此在设计热处理以开发临床适用的 WE43 时存在不确定性。本研究旨在通过应用尖端的原子探针断层扫描技术,提供原子尺度的稀土(RE)富集的β1(Mg3(Y, Nd))和β'(Mg12NdY)纳米相在250 °C的T6热处理诱导下的钝化作用,并采用基于机器学习的图像分析技术,定量揭示WE43在为期12周的植入过程中的体内气体演化,从而推进这一知识的发展。研究发现,纳米化的β1和β'相通过在表面诱导加速钝化效应并限制基质中氢离子的分布,可有效提高WE43的耐腐蚀性。在第 1 周和第 4 周,雌性大鼠的腐蚀率略高于雄性大鼠,但体内氢气量较低,而雄性大鼠体内代谢氢气的能力更强。值得注意的是,尽管第 1 周至第 12 周的腐蚀率逐渐降低,但在第 4 周和第 12 周,发现了与腐蚀率相对应的潜在气体演化。这项研究为工程热处理提供了启示,以开发临床适用的 WE43,使其在不同植入阶段都具有可接受的腐蚀速率和体内气体生成。意义说明:该研究旨在揭示β1和β'纳米相对WE43良好耐腐蚀性的作用。这些纳米相对 WE43 腐蚀性能的影响尚未完全明了。同样,对氢气演化与镁植入物腐蚀速率的关系也缺乏清晰的认识。原子探针断层扫描(APT)表明,β1 和 β' 纳米相会捕获氢气,将 H2 从晶格中移除,使其在镁氧化过程中失去催化作用。计算机断层扫描(CT)图像的机器学习辅助分析表明了潜在的气体演化,这与人们普遍接受的单调的体内 H2 演化相矛盾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Insights into heat treatments of biodegradable Mg-Y-Nd-Zr alloys in clinical settings: Unveiling roles of β' and β1 nanophases and latent in vivo hydrogen evolution

Insights into heat treatments of biodegradable Mg-Y-Nd-Zr alloys in clinical settings: Unveiling roles of β' and β1 nanophases and latent in vivo hydrogen evolution
Heat treatment serves as a viable strategy to effectively mitigate the intense corrosion of biodegradable WE43 alloys. However, limited comprehension of the passivation mechanisms underlying heat treatment and the dilemma to quantitatively examine the evolution of hydrogen gas in vivo introduce uncertainties in designing heat treatments for developing clinically applicable WE43. This work aims to advance this knowledge by applying cutting-edge atom probe tomography to provide atomic-scale insights into the passivation roles of rare earth (RE)-rich β1 (Mg3(Y, Nd)) and β' (Mg12NdY) nanophases induced by T6 heat treatment at 250 °C, and employing machine learning-based image analysis techniques to quantitatively unveil WE43’s in vivo gas evolution during a 12-week implantation. It was found that nanosized β1 and β' phases can effectively improve WE43′s corrosion resistance by inducing an accelerated passivation effect on the surface and confining the distribution of hydrogen ions in the matrix. Female rats presented slightly higher corrosion rates than male rats in weeks 1 and 4 but lower hydrogen gas volumes in vivo, while male rats possessed a superior ability to metabolise hydrogen gas in vivo. Notably, latent gas evolution against the corrosion rates was found which peaked at week 4 and subsided at week 12 despite the gradually decreased corrosion rates from week 1 to 12. This study offers insights for engineering heat treatments to develop clinically applicable WE43 with acceptable corrosion rates and in vivo gas generation at various implantation stages.

Statement of Significance

The study aimed to reveal the role of β1 and β' nanophases on the good corrosion resistance of WE43. The influence of these nanophases on WE43′s corrosion performance has not been totally understood. Similarly, the understanding of hydrogen gas evolution as it relates to the magnesium implant's corrosion rate lacks clarity. Atom probe tomography (APT) indicates β1 and β' nanophases trap hydrogen, removing H2 from the lattice and disabling its catalytic role in Mg oxidation. Machine learning-aided analyses of computed tomography (CT) scan images indicate latent gas evolution, contradicting the monotonic in vivo H2 evolution that is widely accepted.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信