{"title":"研究齐聚物对蛋白质抗性的实验和计算技术。","authors":"Mengyu Lu and Nan Cheng","doi":"10.1039/D4TB01782J","DOIUrl":null,"url":null,"abstract":"<p >Most surfaces undergo non-specific protein adsorption upon direct contact with protein-containing environments, resulting in the formation of a protein corona, and the nature and composition of the corona affect the properties of the material. Zwitterionic polymers have oppositely charged groups in their repeating units, which facilitate the formation of a hydration layer on the surface through electrostatic interactions. The hydration layer possesses a strong water-binding ability and can prevent protein adsorption. Therefore, the hydration effect of zwitterionic polymers has become a research focus, and many researchers have investigated this mechanism using experimental and computational methods. This paper reviews the experimental techniques and simulation methods to study the hydration effect of zwitterionic polymers and the advantages and disadvantages of different techniques are discussed.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 1","pages":" 103-116"},"PeriodicalIF":6.1000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Experimental and computational techniques to investigate the protein resistance of zwitterionic polymers\",\"authors\":\"Mengyu Lu and Nan Cheng\",\"doi\":\"10.1039/D4TB01782J\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Most surfaces undergo non-specific protein adsorption upon direct contact with protein-containing environments, resulting in the formation of a protein corona, and the nature and composition of the corona affect the properties of the material. Zwitterionic polymers have oppositely charged groups in their repeating units, which facilitate the formation of a hydration layer on the surface through electrostatic interactions. The hydration layer possesses a strong water-binding ability and can prevent protein adsorption. Therefore, the hydration effect of zwitterionic polymers has become a research focus, and many researchers have investigated this mechanism using experimental and computational methods. This paper reviews the experimental techniques and simulation methods to study the hydration effect of zwitterionic polymers and the advantages and disadvantages of different techniques are discussed.</p>\",\"PeriodicalId\":83,\"journal\":{\"name\":\"Journal of Materials Chemistry B\",\"volume\":\" 1\",\"pages\":\" 103-116\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2024-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Materials Chemistry B\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d4tb01782j\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Chemistry B","FirstCategoryId":"1","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d4tb01782j","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Experimental and computational techniques to investigate the protein resistance of zwitterionic polymers
Most surfaces undergo non-specific protein adsorption upon direct contact with protein-containing environments, resulting in the formation of a protein corona, and the nature and composition of the corona affect the properties of the material. Zwitterionic polymers have oppositely charged groups in their repeating units, which facilitate the formation of a hydration layer on the surface through electrostatic interactions. The hydration layer possesses a strong water-binding ability and can prevent protein adsorption. Therefore, the hydration effect of zwitterionic polymers has become a research focus, and many researchers have investigated this mechanism using experimental and computational methods. This paper reviews the experimental techniques and simulation methods to study the hydration effect of zwitterionic polymers and the advantages and disadvantages of different techniques are discussed.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices