通过聚合诱导自组装试验制备的具有光热活性的铁基纳米酶可促进细菌感染伤口的愈合。

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Xuan Nie , Ling Fu , An-Pin Guo , Lei Zhang , Shao-Hu Huo , Wen Zhang , Zhao-Lin Chen , Xiang Zhan , Li-Qin Tang , Fei Wang
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引用次数: 0

摘要

如今,抗生素的过度使用已使细菌感染升级为日益严重的全球健康威胁。开发非抗生素疗法已成为治疗细菌感染的一种前景广阔的策略。其中,以纳米酶为基础的复合材料越来越受到人们的关注。因此,高效制备纳米酶非常重要。在此,我们提出了一种通过聚合诱导自组装试验制备铁基纳米酶的高效方法,以高效杀灭细菌,从而显著促进感染伤口的愈合。通过聚合诱导自组装试验,可以有效制备出大量大小均匀、带有咪唑基团的胶束。这些纳米颗粒随后与铁离子螯合,再经过热解和蚀刻过程,最终生成了尺寸均匀、在近红外区域具有高吸附活性的小尺寸纳米酶。这种复合材料可在感染的微环境下通过光热和催化疗法的协同策略有效消灭细菌。全厚伤口的活体动物模型显示,联合疗法不仅能消灭 98% 的细菌,还能显著加快伤口愈合。这项工作强调了聚合诱导自组装在制备纳米酶中的实用性,并揭示了纳米酶在伤口愈合中的应用前景。意义说明:这项研究介绍了一种通过聚合诱导自组装合成的具有光热活性的功能纳米酶,为抗击细菌感染提供了一种前景广阔的非抗生素策略。这种策略结合了光热疗法和催化疗法,能有效消灭耐药细菌,同时最大限度地减少对健康组织的损害,从而促进伤口愈合。我们的研究结果对开发先进的抗菌疗法具有重要意义,并为制备小尺寸纳米酶提供了一种可靠的检测方法。制备的功能性纳米粒子在伤口愈合方面具有潜力,解决了抗生素耐药性不断增加的关键需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fe-based nanozyme with photothermal activity prepared from polymerization-induced self-assembly assays boosts the recovery of bacteria-infected wounds

Fe-based nanozyme with photothermal activity prepared from polymerization-induced self-assembly assays boosts the recovery of bacteria-infected wounds
Nowadays, the overuse of antibiotics has escalated bacterial infections into an increasingly severe global health threat. Developing non-antibiotic treatments has emerged as a promising strategy for treating bacterial infections. Notably, nanozyme-based composite materials have garnered growing interest. Therefore, the efficient preparation of nanozyme is important. Herein, we have presented an efficient method to prepare Fe-based nanozyme through polymerization-induced self-assembly assay to kill bacteria efficiently, which could significantly enhance the healing of infected wounds. Through polymerization-induced self-assembly assay, a large number of uniformly sized micelles, bearing imidazole groups, could be efficiently prepared. These nanoparticles subsequently chelate with Fe ions, followed by pyrolysis and etching processes, resulting in the production of uniformly small-sized nanozymes with high adsorption activity in the near-infrared region. The composite materials could effectively eradicate bacteria via a synergistic strategy of photothermal and catalytic therapies under infected microenvironments. In vivo animal models with full-thickness wounds showed that combination therapy not only eradicates 98 % of the bacteria but also significantly accelerates wound healing. This work underscores the utility of polymerization-induced self-assembly in the preparation of nanozymes and reveals promising applications of nanozymes in wound healing.

Statement of significance

This research introduces a functional nanozyme with photothermal activity, synthesized through polymerization-induced self-assembly, offering a promising non-antibiotic strategy to combat bacterial infections. This strategy enhances wound healing by combining photothermal and catalytic therapies, effectively eradicating drug-resistant bacteria while minimizing damage to healthy tissue. Our findings hold significant implications for the development of advanced antibacterial treatments and offer a robust assay to prepare nanozyme with small sizes. The prepared functional nanoparticles have a potential in wound healing, addressing a critical need in the face of rising antibiotic resistance.
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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