{"title":"低聚物重排可调节通道活性。","authors":"Yue Ren, Xue Yang, Yuequan Shen","doi":"10.52601/bpr.2023.230018","DOIUrl":null,"url":null,"abstract":"<p><p>Channels are typically gated by several factors, including voltage, ligand and mechanical force. Most members of the calcium homeostasis modulator (CALHM) protein family, large-pore ATP release channels, exist in different oligomeric states. Dynamic conversions between CALHM1 heptamers and octamers to gate the channel were proposed. Meanwhile, the latest study observed that the transient receptor potential vanilloid 3 (TRPV3) channel adopts a dynamic transition between pentamers and canonical tetramers in response to small molecule treatment. These results suggest that oligomeric rearrangement may add a new layer to regulate the channel activities.</p>","PeriodicalId":93906,"journal":{"name":"Biophysics reports","volume":"10 5","pages":"293-296"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554575/pdf/","citationCount":"0","resultStr":"{\"title\":\"Oligomeric rearrangement may regulate channel activity.\",\"authors\":\"Yue Ren, Xue Yang, Yuequan Shen\",\"doi\":\"10.52601/bpr.2023.230018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Channels are typically gated by several factors, including voltage, ligand and mechanical force. Most members of the calcium homeostasis modulator (CALHM) protein family, large-pore ATP release channels, exist in different oligomeric states. Dynamic conversions between CALHM1 heptamers and octamers to gate the channel were proposed. Meanwhile, the latest study observed that the transient receptor potential vanilloid 3 (TRPV3) channel adopts a dynamic transition between pentamers and canonical tetramers in response to small molecule treatment. These results suggest that oligomeric rearrangement may add a new layer to regulate the channel activities.</p>\",\"PeriodicalId\":93906,\"journal\":{\"name\":\"Biophysics reports\",\"volume\":\"10 5\",\"pages\":\"293-296\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554575/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biophysics reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52601/bpr.2023.230018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52601/bpr.2023.230018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
通道通常受多种因素（包括电压、配体和机械力）的制约。钙平衡调节蛋白（CALHM）家族的大多数成员是大孔 ATP 释放通道，它们以不同的寡聚状态存在。有人提出了 CALHM1 七聚体和八聚体之间的动态转换，以关闭通道。同时，最新研究观察到，瞬态受体电位类香草素 3（TRPV3）通道在小分子处理下会在五聚体和标准四聚体之间发生动态转换。这些结果表明，低聚物重排可能为调控通道活性增加了一个新的层次。
Oligomeric rearrangement may regulate channel activity.
Channels are typically gated by several factors, including voltage, ligand and mechanical force. Most members of the calcium homeostasis modulator (CALHM) protein family, large-pore ATP release channels, exist in different oligomeric states. Dynamic conversions between CALHM1 heptamers and octamers to gate the channel were proposed. Meanwhile, the latest study observed that the transient receptor potential vanilloid 3 (TRPV3) channel adopts a dynamic transition between pentamers and canonical tetramers in response to small molecule treatment. These results suggest that oligomeric rearrangement may add a new layer to regulate the channel activities.
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