生物衰老在不健康老龄化中的作用有限：对全球预期寿命和残疾数据的横断面分析。

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-11-07 DOI:10.1016/j.archger.2024.105691

Wenpeng You , Luisa Garcia , Kamal Hezam , Hui Chen (Rita) Chang

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引用次数: 0

摘要

背景众所周知，生物老化会影响生活质量，但其确切作用还存在争议：本研究探讨了以出生时预期寿命（e0）衡量的生物老龄化如何影响以残疾损失年数（YLD）表示的不健康老龄化：分析了来自国际组织的数据，包括 e0、YLD 以及收入、肥胖和城市化等混杂因素。相关性用散点图表示，关联性用皮尔逊法和非参数法评估。为了确定 e0 对 YLD 的影响，进行了局部、多层次建模和多元回归分析。在对混杂因素进行调整后，e0 的贡献降至 12.18%。多元回归确定 e0 和城市化是重要的预测因素：结论：生物老龄化会影响 YLD，但在考虑其他因素后，其影响会减弱，这突出表明需要采取综合方法来实现健康老龄化。

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Limited role of biological aging in unhealthy aging: A cross-sectional analysis of global life expectancy and disability data

Background

Biological aging is known to impact quality of life, but its precise role is debated.

Objective

This study explores how biological aging, measured by life expectancy at birth (e0), affects unhealthy aging as indicated by years lost due to disability (YLD).

Methods

Data from international organizations, including e0, YLD, and confounding factors like income, obesity, and urbanization, were analyzed. Correlations were visualized with scatter plots, and associations were assessed using Pearson's and nonparametric methods. Partial, multilevel modelling and multiple regression analyses were conducted to determine e0′s impact on YLD.

Results

e0 strongly correlated with YLD, explaining about 50 % of its variance. After adjusting for confounders, e0’s contribution fell to 12.18 %. Multiple regression identified e0 and urbanization as significant predictors.

Conclusions

Biological aging influences YLD, but its effect diminishes when accounting for other factors, highlighting the need for a comprehensive approach to healthy aging.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.