氨基酸 PET 在成人型弥漫性胶质瘤放疗靶区划分中的作用：文献综述。

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2024-11-08 DOI:10.1016/j.critrevonc.2024.104552

Patrick J. Horsley , Dale L. Bailey , Geoffrey Schembri , Edward Hsiao , James Drummond , Michael F. Back

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引用次数: 0

摘要

目的：总结研究氨基酸正电子发射断层扫描（AA-PET）用于胶质瘤患者放疗靶区划分的现有文献：方法：系统检索 MEDLINE 和 EMBASE 数据库：结果：20 项研究符合纳入标准。比较核磁共振成像和 AA-PET 得出的靶体积的研究一致认为两者具有互补性。在所有研究中，AA-PET是预测后续复发部位的有力指标。在以标准剂量进行AA-PET引导放疗的研究中，包括一项使用缩小边缘的研究，生存结果与仅使用MRI生成体积的历史队列相似。四项前瞻性单臂试验对AA-PET引导的剂量递增放疗进行了研究，结果不一。两项试验同时使用了较高的生物有效剂量，并使用MRI和AA-PET确定了增量，结果令人鼓舞：结论：AA-PET是核磁共振成像在放射治疗靶区划分方面一种很有前途的补充工具，其潜在优势需要进一步验证，包括减少边缘和促进剂量递增。

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The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: A review of the literature

Purpose

To summarise existing literature examining amino acid positron emission tomography (AA-PET) for radiotherapy target volume delineation in patients with gliomas.

Methods

Systematic search of MEDLINE and EMBASE databases.

Results

Twenty studies met inclusion criteria. Studies comparing MRI- and AA-PET- derived target volumes consistently found these to be complementary. Across studies, AA-PET was a strong predictor of the site of subsequent relapse. In studies examining AA-PET-guided radiotherapy at standard doses, including one study using reduced margins, survival outcomes were similar to historical cohorts whose volumes were generated using MRI alone. Four prospective single-arm trials examining AA-PET-guided dose-escalated radiotherapy reported mixed results. The two trials that used both a higher biologically-effective dose and boost-volumes defined using both MRI and AA-PET reported promising outcomes.

Conclusion

AA-PET is a promising complementary tool to MRI for radiotherapy target volume delineation, with potential benefits requiring further validation including margin reduction and facilitation of dose-escalation.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.