轻度脑外伤灰质体积变化的转录特征。

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2024-11-12 DOI:10.1016/j.pnpbp.2024.111195

Lu Wang , He Wang , Yijing Zhang , Mengjing Cai , Zhihui Zhang , Minghuan Lei , Yujie Zhang , Jiaxuan Zhao , Ying Wang , Jinglei Xu , Ying Zhai , Jinghan Sun , Qi An , Wenjie Cai , Yifan Jiang , Feng Liu , Yanmin Peng , Lining Guo

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引用次数: 0

摘要

背景：神经影像学研究表明，轻度创伤性脑损伤（mTBI）患者的大脑灰质体积（GMV）通常会发生变化。然而，有关这些变化的结果并不一致，其潜在的分子机制也仍不清楚。本研究旨在调查 mTBI 患者的灰质体积变化，并揭示驱动这些变化的分子机制：我们对涉及 396 名 mTBI 患者和 338 名健康对照者的九项研究进行了神经影像学荟萃分析，以确定 GMV 变化的一致模式。此外，我们还利用艾伦人脑图谱数据库（Allen Human Brain Atlas database）探讨了转录组-神经影像学空间相关性，确定了其表达谱与 mTBI 患者 GMV 变化相关的基因。我们还进行了富集分析，以确定 GMV 相关基因变化的生物学意义：结果：我们观察到双侧扣带回/扣带回中部、右侧纹状体和右侧额叶背外侧上回的 GMV 持续增加，而右侧脑岛和左侧舌回的 GMV 则持续减少。此外，我们还发现了与 mTBI 相关的 GMV 变化与 977 个基因表达之间的空间关联，这些基因主要富集在大脑皮层的特定生物过程、身体组织和发育时间窗中：我们的研究结果增进了人们对 mTBI 患者 GMV 异常的了解，并为这些变化的分子机制提供了见解。

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Transcriptional signatures of gray matter volume changes in mild traumatic brain injury

Background

Neuroimaging studies have shown that patients with mild traumatic brain injury (mTBI) often exhibit changes in gray matter volume (GMV) in the brain. However, the results regarding these changes are inconsistent, and the underlying molecular mechanisms remain unclear. This study aimed to investigate GMV changes in mTBI patients and uncover the molecular mechanisms driving these alterations.

Methods

We conducted a neuroimaging meta-analysis on nine studies, involving 396 mTBI patients and 338 healthy controls, to identify consistent patterns of GMV changes. Additionally, we utilized the Allen Human Brain Atlas database to explore transcriptome-neuroimaging spatial correlations, identifying genes whose expression profiles are linked to GMV changes in mTBI patients. Enrichment analyses were also performed to determine the biological significance of the altered GMV-related genes.

Results

We observed consistent GMV increases in the bilateral middle cingulate/paracingulate gyri, right striatum, and right dorsolateral superior frontal gyrus, along with GMV decreases in the right insula and left lingual gyrus. Moreover, we found spatial associations between mTBI-related GMV changes and the expression of 977 genes, which were primarily enriched in specific biological processes, body tissues, and developmental time windows of the cerebral cortex.

Conclusion

Our findings improve the understanding of GMV abnormalities in mTBI patients and provide insights into the molecular mechanisms underlying these changes.

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.