鼻窦粘膜黑色素瘤中存在色素失禁现象

IF 2.2 3区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Laryngoscope Pub Date : 2024-11-14 DOI:10.1002/lary.31901
Shreya Mandloi, Stacey Mardekian Gargano, Alexander N Duffy, Peter A Benedict, Samuel R Shing, Chase Kahn, Paavali Hannikainen, Juan Pablo Pineda-Reyes, David Bray, Elina M Toskala, Mindy Rabinowitz, Marc Rosen, Christopher Farrell, James J Evans, Gurston G Nyquist
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引用次数: 0

摘要

背景:消退是皮肤黑色素瘤中的一种免疫现象,在这种现象中,肿瘤被肿瘤浸润的淋巴细胞、肉芽组织和成熟的成纤维细胞所取代,并经常伴有色素失禁(黑色素在真皮上层的积聚)。色素失禁会导致严重的色素性病变,可能会被误认为是存活的肿瘤,但在鼻窦粘膜黑色素瘤(SNMM)中还没有出现过这种情况。本研究调查了鼻窦粘膜黑色素瘤患者中是否存在退行性病变和色素失禁:方法:对2007年至2023年的SNMM患者进行了回顾性病历审查。手术切除的病理切片由两名病理学家进行检查,他们对治疗信息保密,以确定是否存在色素沉着的巨噬细胞及其范围,以及退行性色素沉着的其他组织病理学特征:17名SNMM患者接受了手术切除。三名患者接受了新辅助治疗,随后进行了手术切除。94%的患者出现了肿瘤消退,65%的患者出现了色素失禁,新辅助治疗患者和未接受治疗的患者均出现了色素失禁。接受新辅助治疗的三名患者均有色素失禁的证据:讨论:本研究强调了SNMM经常表现出回归的特征。本研究是首次描述SNMM患者色素失禁的研究之一。色素失禁可能是肿瘤自然生命周期的一部分,严重的色素性病变很容易与黑色素瘤混淆,尤其是在新辅助治疗后。了解SNMM的消退和色素失禁对诊断和临床管理非常重要:IV 《喉镜》,2024 年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Presence of Pigment Incontinence in Sinonasal Mucosal Melanoma.

Background: Regression is an immunological phenomenon described in cutaneous melanoma whereby tumor is replaced with tumor-infiltrating lymphocytes, granulation tissue, and mature fibroblasts often accompanied by pigment incontinence (accumulation of melanin in the upper dermis). Pigment incontinence results in grossly pigmented lesions that may be mistaken for viable tumor and has not been described in sinonasal mucosal melanoma (SNMM). This study investigates the presence of regression and pigment incontinence in patients with SNMM.

Methods: A retrospective chart review was conducted on SNMM patients from 2007 to 2023. Pathology slides from surgical resection were examined by two pathologists blinded to treatment information for the presence and extent of pigment-laden macrophages and other histopathologic features of regression.

Results: Seventeen patients with SNMM were included in this study who underwent surgical resection. Three patients received neoadjuvant therapy followed by surgical resection. Regression was present in 94% of patients and pigment incontinence was present in 65% of patients and occurred in both neoadjuvant treated patients and treatment naïve patients. All three patients with neoadjuvant treatment had evidence of pigment incontinence.

Discussion: This study highlights that SNMM often displays characteristics of regression. This study is one of the first to describe the presence of pigment incontinence in patients with SNMM. Pigment incontinence can be a part of the natural tumor life cycle and grossly pigmented lesions could easily be confused for melanoma especially after neoadjuvant therapy. Developing an understanding of regression and pigment incontinence within SNMM is important for diagnosis and clinical management.

Level of evidence: IV Laryngoscope, 2024.

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来源期刊
Laryngoscope
Laryngoscope 医学-耳鼻喉科学
CiteScore
6.50
自引率
7.70%
发文量
500
审稿时长
2-4 weeks
期刊介绍: The Laryngoscope has been the leading source of information on advances in the diagnosis and treatment of head and neck disorders since 1890. The Laryngoscope is the first choice among otolaryngologists for publication of their important findings and techniques. Each monthly issue of The Laryngoscope features peer-reviewed medical, clinical, and research contributions in general otolaryngology, allergy/rhinology, otology/neurotology, laryngology/bronchoesophagology, head and neck surgery, sleep medicine, pediatric otolaryngology, facial plastics and reconstructive surgery, oncology, and communicative disorders. Contributions include papers and posters presented at the Annual and Section Meetings of the Triological Society, as well as independent papers, "How I Do It", "Triological Best Practice" articles, and contemporary reviews. Theses authored by the Triological Society’s new Fellows as well as papers presented at meetings of the American Laryngological Association are published in The Laryngoscope. • Broncho-esophagology • Communicative disorders • Head and neck surgery • Plastic and reconstructive facial surgery • Oncology • Speech and hearing defects
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