美国成年人甘油三酯-葡萄糖-体重指数与抑郁症之间的关系：一项横断面研究。

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2024-11-11 DOI:10.1016/j.puhe.2024.10.032

Lu Zhang , Haiyang Sun , Jiahui Yin , Zerun Zhang , Jiguo Yang , Yuanxiang Liu

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引用次数: 0

摘要

目的：甘油三酯血糖-体重指数（TyG-BMI）是胰岛素抵抗的公认替代指标。虽然胰岛素抵抗与抑郁症之间的关系已被确认，但 TyG-BMI 与抑郁症之间的关系仍不清楚。因此，我们利用美国国家健康与营养调查（NHANES）数据库中的数据对此进行了研究：这项横断面研究纳入了 2011 年至 2020 年美国国家健康与营养调查（NHANES）中的 9673 名成年人（年龄≥20 岁）：抑郁症状采用九项患者健康问卷进行评估。协变量包括年龄、性别、种族/民族、婚姻状况、教育程度、贫困收入比、吸烟状况、酒精摄入量、糖尿病状况、心血管疾病、高血压、体力活动、高密度脂蛋白、低密度脂蛋白和总胆固醇。研究人员进行了多变量逻辑回归模型、亚组分析和阈值饱和效应分析：在对年龄、性别、种族/民族、婚姻状况、教育水平、贫困收入比、吸烟状况、饮酒状况、糖尿病状况、心血管疾病、高血压、体力活动、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇进行调整后，阈值饱和效应显示 TyG-BMI 拐点为 174.4。在拐点以下，TyG-BMI 每增加 10 个单位，抑郁症患病率就会降低 12%。在拐点之上，TyG-BMI 每增加 10 个单位，抑郁症患病率就会增加 4%：结论：TyG-BMI 与抑郁症患病率呈 U 型关系。结论：TyG-BMI 与抑郁症患病率呈 U 型关系，TyG-BMI 水平越高，抑郁症患病率越高。当TyG-BMI值低于174.4时，TyG-BMI的进一步增加与抑郁症患病率的显著降低有关。

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Association between triglyceride glucose-body mass index and depression among US adults: A cross-sectional study

Objectives

The triglyceride glucose-body mass index (TyG-BMI) is a well-established surrogate marker for insulin resistance. While an association between insulin resistance and depression has been identified, that between TyG-BMI and depression remains unclear. Therefore, we used data from the National Health and Nutrition Examination Survey (NHANES) database to investigate this.

Study design

This cross-sectional study included 9673 adults (aged ≥20 years) from the NHANES in the United States from 2011 to 2020.

Methods

Depressive symptoms were assessed using a nine-item version of the Patient Health Questionnaire. The covariates included age, sex, race/ethnicity, marital status, educational level, poverty-income ratio, smoking status, alcohol intake, diabetes status, cardiovascular disease, hypertension, physical activity, high-density lipoprotein, low-density lipoprotein, and total cholesterol. Multivariate logistic regression models, subgroup analyses, and threshold saturation effect analyses were conducted.

Results

After adjusting for age, sex, race/ethnicity, marital status, education level, poverty-income ratio, smoking status, drinking status, diabetes status, cardiovascular disease, hypertension, physical activity, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, the threshold saturation effect showed a TyG-BMI inflection point of 174.4. Below the inflection point, a 10-unit increase in TyG-BMI was associated with a 12 % lower prevalence of depression. Above the inflection point, each 10-unit increase in TyG-BMI was associated with a 4 % increase in prevalence of depression.

Conclusions

TyG-BMI had a U-shaped relationship with prevalence of depression. There was a significant link between higher TyG-BMI levels and increased prevalence of depression. When the TyG-BMI value was below 174.4, any further increase in TyG-BMI was associated with a significantly lower prevalence of depression.

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.