来自 Viscum coloratum (Kom.) Nakai 的细胞毒性化合物。

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-11-14 DOI:10.1515/znc-2023-0170

Bo Wen, Juan Pan, Xin Meng, Zhi-Chao Hao, Wei Guan, Hai-Xue Kuang, Qing-Shan Chen, Li-Li Zhang, Yan Liu, Bing-You Yang

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引用次数: 0

摘要

从 Viscum coloratum (Kom.) Nakai 中分离出了两种新化合物（1-2）和一种新的人工产物（3）以及 15 种已知化合物（4-18）。通过分析这些化合物的光谱数据（包括 MS、1D 和 2D NMR 光谱）以及与现有文献的比较，确定了它们的结构。评估了所有化合物对 4T1 和 LN229 细胞（以顺铂为阳性对照）的细胞毒活性，结果表明化合物 3、4 和 5 的抗 LN229 细胞毒性高于 4T1 细胞。

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Cytotoxic compounds from Viscum coloratum (Kom.) Nakai.

Two new compounds (1-2) and a new artificial product (3) together with fifteen known compounds (4-18) were isolated from Viscum coloratum (Kom.) Nakai. Their structures were established by analysis of their spectroscopic data including MS, 1D and 2D NMR spectra, and comparison with existing literature. All the compounds were assessed for their cytotoxic activity against 4T1 and LN229 cells (with cisplatin as the positive control), and the anti-LN229 cytotoxicity of compounds 3, 4 and 5 were greater than that of 4T1 cells.

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.