Yutang Wang, Yan Fang, Andreas J. R. Habenicht, Jonathan Golledge, Edward L. Giovannucci, Antonio Ceriello
{"title":"空腹时间为 4-7.9 小时的餐后血浆葡萄糖与美国成年人的癌症死亡率呈正相关。","authors":"Yutang Wang, Yan Fang, Andreas J. R. Habenicht, Jonathan Golledge, Edward L. Giovannucci, Antonio Ceriello","doi":"10.1002/dmrr.70008","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aims</h3>\n \n <p>This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort of US adults.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>This cohort study included 14,860 US adults who attended the third National Health and Nutrition Examination Survey from 1988 to 1994, with mortality being followed up until December 31, 2019. The explanatory variable was the level of plasma glucose, including PPG with a fasting time of 0–3.9 h (PPG<sub>0–3.9h</sub>) and 4–7.9 h (PPG<sub>4–7.9h</sub>), plasma glucose with a fasting time ≥8 h (PG<sub>fasting</sub>), and plasma glucose at 2 h after oral glucose tolerance test (PG<sub>2hOGTT</sub>). Plasma glucose-associated cancer mortality risk was assessed using Cox proportional hazard models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A 1-natural-log-unit increase in PPG<sub>4–7.9h</sub> was associated with a higher multivariate-adjusted risk for cancer mortality [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50–7.00]. However, PPG<sub>0–3.9h</sub>, PG<sub>fasting</sub>, PG<sub>2hOGTT</sub>, haemoglobin A<sub>1c</sub>, and insulin were not significantly associated with cancer mortality. The positive association of PPG<sub>4–7.9h</sub> with cancer mortality remained in those without a prior diagnosis of cancer.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>High PPG<sub>4–7.9h</sub> is associated with a higher cancer mortality risk in US adults. Lowering PPG<sub>4–7.9h</sub> may reduce cancer mortality.</p>\n </section>\n </div>","PeriodicalId":11335,"journal":{"name":"Diabetes/Metabolism Research and Reviews","volume":"40 8","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Postprandial Plasma Glucose With a Fasting Time of 4–7.9 h Is Positively Associated With Cancer Mortality in US Adults\",\"authors\":\"Yutang Wang, Yan Fang, Andreas J. R. Habenicht, Jonathan Golledge, Edward L. Giovannucci, Antonio Ceriello\",\"doi\":\"10.1002/dmrr.70008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p>This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort of US adults.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>This cohort study included 14,860 US adults who attended the third National Health and Nutrition Examination Survey from 1988 to 1994, with mortality being followed up until December 31, 2019. The explanatory variable was the level of plasma glucose, including PPG with a fasting time of 0–3.9 h (PPG<sub>0–3.9h</sub>) and 4–7.9 h (PPG<sub>4–7.9h</sub>), plasma glucose with a fasting time ≥8 h (PG<sub>fasting</sub>), and plasma glucose at 2 h after oral glucose tolerance test (PG<sub>2hOGTT</sub>). Plasma glucose-associated cancer mortality risk was assessed using Cox proportional hazard models.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>A 1-natural-log-unit increase in PPG<sub>4–7.9h</sub> was associated with a higher multivariate-adjusted risk for cancer mortality [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50–7.00]. However, PPG<sub>0–3.9h</sub>, PG<sub>fasting</sub>, PG<sub>2hOGTT</sub>, haemoglobin A<sub>1c</sub>, and insulin were not significantly associated with cancer mortality. The positive association of PPG<sub>4–7.9h</sub> with cancer mortality remained in those without a prior diagnosis of cancer.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>High PPG<sub>4–7.9h</sub> is associated with a higher cancer mortality risk in US adults. 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Postprandial Plasma Glucose With a Fasting Time of 4–7.9 h Is Positively Associated With Cancer Mortality in US Adults
Aims
This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort of US adults.
Materials and Methods
This cohort study included 14,860 US adults who attended the third National Health and Nutrition Examination Survey from 1988 to 1994, with mortality being followed up until December 31, 2019. The explanatory variable was the level of plasma glucose, including PPG with a fasting time of 0–3.9 h (PPG0–3.9h) and 4–7.9 h (PPG4–7.9h), plasma glucose with a fasting time ≥8 h (PGfasting), and plasma glucose at 2 h after oral glucose tolerance test (PG2hOGTT). Plasma glucose-associated cancer mortality risk was assessed using Cox proportional hazard models.
Results
A 1-natural-log-unit increase in PPG4–7.9h was associated with a higher multivariate-adjusted risk for cancer mortality [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50–7.00]. However, PPG0–3.9h, PGfasting, PG2hOGTT, haemoglobin A1c, and insulin were not significantly associated with cancer mortality. The positive association of PPG4–7.9h with cancer mortality remained in those without a prior diagnosis of cancer.
Conclusions
High PPG4–7.9h is associated with a higher cancer mortality risk in US adults. Lowering PPG4–7.9h may reduce cancer mortality.
期刊介绍：
Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.
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