[青岛市某医院 9 528 名孕早期孕妇的抗核抗体分析]。

Q3 Medicine
S Kang, G L Hao, X Y Jing, M Z Guo, L Zhao, J H Dong, S Wang, M L Wu, M R Wu, Q Xu, J L Song
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引用次数: 0

摘要

目的:分析青岛地区孕早期健康孕妇抗核抗体(ANA)的阳性率、滴度、核型及靶抗原。本研究采用前瞻性队列研究设计,纳入了 2023 年 3 月至 2024 年 6 月期间在青岛大学附属妇女儿童医院登记的 9 528 名健康孕妇,采用间接免疫荧光法(IIF)检测 ANA 及其滴度和细胞染色模式。采用磁条编码免疫荧光发光法检测 15 种特异性抗体。采用逻辑回归模型分析妊娠合并自身免疫性疾病(AID)的风险因素。结果显示,在 9 528 名孕早期孕妇中,有 1 346 例(14.1%)ANA 阳性,其中滴度为 1∶100 的有 1 011 例(10.6%),滴度为 1∶320 的有 236 例(2.5%),滴度大于 1∶320 的有 99 例(1.0%)。在 1 346 名 ANA 阳性孕妇中,核颗粒型所占比例最高(483 例,35.9%),其次是斑点型(347 例,25.8%)和细胞质型(176 例,13.1%)。其中121例检测到抗SSA抗体,占大多数,其次是110例抗Ro-52抗体、56例抗SSB抗体、51例抗线粒体M2亚型抗体和37例抗中心粒B抗体。综上所述,青岛地区健康孕妇ANA阳性率为14.1%,ANA滴度以1∶100为主,核型以核颗粒型和核斑点型为主,特异性自身抗体以抗SSA抗体和抗Ro-52抗体为主,ANA和特异性自身抗体的检测对妊娠期自身免疫性疾病的早期预测、诊断和干预具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Analysis of antinuclear antibody in 9 528 pregnant women during early pregnancy in a hospital in Qingdao City].

To analyze the positivity rate and titer of antinuclear antibody (ANA), as well as nuclear pattern and target antigen of ANA in healthy pregnant women during early pregnancy in Qingdao area. A prospective cohort study design was used to include a total of 9 528 healthy pregnant women registered at the Women and Children's Hospital Affiliated to Qingdao University from March 2023 to June 2024.Indirect immunofluorescence assay (IIF) was used to detect ANA, its titer and cell staining pattern. Fifteen specific antibodies were tested using the magnetic bar code immunofluorescent luminescence method. Logistic regression model was used to analyze the risk factors of pregnancy with autoimmune disease(AID). The results showed that among 9 528 pregnant women in early pregnancy, 1 346 cases (14.1%) were positive of ANA, including 1 011 cases with a titer of 1∶100 (10.6%), 236 cases (2.5%) with a titer of 1∶320, and 99 cases (1.0%) were detected at a titer >1∶320. Among the 1 346 ANA-positive pregnant women, nuclear granular type accounted for the highest proportion (483 cases, 35.9%), followed by speckled type (347 cases, 25.8%) and cytoplasmic type (176 cases, 13.1%).Then, pregnant women with ANA titers ≥1∶100 were detected 15 specific antibodies.Anti-SSA was tested in 121 cases accounted for the majority, followed by 110 cases with anti-Ro-52, 56 cases with anti-SSB, 51 cases with anti-mitochondrial M2 subtype antibodies and 37 cases with anti-centromere B. In conclusion,in healthy pregnant women in Qingdao area, ANA positivity rate was 14.1%, and the titer of ANA was mainly at 1∶100.The predominant nuclear patterns were nuclear granular and speckled types.The specific autoantibodies were mainly anti-SSA antibodies and anti-Ro-52 antibodies.The detection of ANA and specific autoantibodies is of great significance for early prediction, diagnosis, and intervention of autoimmune diseases during pregnancy.

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来源期刊
中华预防医学杂志
中华预防医学杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
12678
期刊介绍: Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.
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