与年龄有关的睾酮下降:机制和干预策略。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Haoyang Cheng, Xiaoyan Zhang, Yongheng Li, Dezhong Cao, Chenglong Luo, Qi Zhang, Sizheng Zhang, Yongzheng Jiao
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引用次数: 0

摘要

当代社会呈现出生育年龄推迟和预期寿命延长的特点。虽然与女性相比,男性生殖系统的衰老相对较晚,但年龄的增长会对其功能产生重大影响。一个典型的表现就是年龄引起的睾酮下降。睾酮是一种重要的男性性激素,在精子生成和性功能方面起着关键作用,并对新陈代谢、心理和心血管健康有重要影响。衰老对下丘脑-垂体-性腺轴和雷迪格细胞产生深远影响,导致睾酮减少,从而对男性健康产生不利影响。外源性睾酮补充剂可部分改善与年龄相关的睾酮缺乏症,但其长期安全性仍存在争议。作为一种潜在的干预策略,在衰老过程中保持内源性睾酮的生产能力值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-related testosterone decline: mechanisms and intervention strategies.

Contemporary societies exhibit delayed reproductive age and increased life expectancy. While the male reproductive system demonstrates relatively delayed aging compared to that of females, increasing age substantially impacts its function. A characteristic manifestation is age-induced testosterone decline. Testosterone, a crucial male sex hormone, plays pivotal roles in spermatogenesis and sexual function, and contributes significantly to metabolism, psychology, and cardiovascular health. Aging exerts profound effects on the hypothalamic-pituitary-gonadal axis and Leydig cells, precipitating testosterone reduction, which adversely affects male health. Exogenous testosterone supplementation can partially ameliorate age-related testosterone deficiency; however, its long-term safety remains contentious. Preserving endogenous testosterone production capacity during the aging process warrants further investigation as a potential intervention strategy.

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来源期刊
Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology 医学-内分泌学与代谢
CiteScore
7.90
自引率
2.30%
发文量
161
审稿时长
4-8 weeks
期刊介绍: Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.
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