毛蕊花提取物通过抑制 MAPK 信号传导减轻紫外线-B 引起的无毛小鼠皮肤损伤

IF 2.5 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-11-01 DOI:10.1111/phpp.13011

Ki Mo Kim, A-Rang Im, Ki-Shuk Shim, A Yeong Lee, Taesoo Kim, Sung-A Choi, Kung-Woo Nam, Sanghyun Lee, Jin Won Hyun, Sungwook Chae

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引用次数: 0

摘要

背景：暴露在太阳紫外线-B（UV-B）辐射下会诱导基质金属蛋白酶（MMPs）（如 MMP-1）的表达，导致细胞外基质的改变和随之而来的光老化，从而明显加速皮肤老化。一些植物成分以其吸收紫外线和抗氧化特性而闻名，它们通过降低紫外线-B 诱导的 MMP 水平，显示出缓解光老化的潜力。在此背景下，我们探讨了三疣檗提取物（CTE）对紫外线-B 诱导的皮肤损伤的抑制作用：方法：采用网络药理学方法预测了 CTE 的作用机制。方法：采用网络药理学方法预测 CTE 的作用机制，并通过小鼠模型和人表皮角质细胞（HEKa）细胞系统评估其抗衰老功效，包括其对丝裂原活化蛋白激酶（MAPK）信号通路的调节作用：结果：CTE 能有效对抗紫外线-B 引起的皮肤损伤，小鼠体内 MMP-9 和 MMP-1 的表达受到抑制就证明了这一点。我们发现，CTE 的每种组分和化学成分都能抑制 HEKa 细胞中紫外线-B 诱导的 MMP-1 分泌：结论：CTE 可通过调节 MAPK 信号通路部分抑制 MMP-1 和 MMP-9 的分泌，从而抑制紫外线-B 诱导的皮肤老化。

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Clerodendrum trichotomum Extract Attenuates UV-B-Induced Skin Impairment in Hairless Mice by Inhibiting MAPK Signaling.

Background: Exposure to solar ultraviolet-B (UV-B) radiation significantly accelerates skin aging by inducing the expression of matrix metalloproteinases (MMPs) such as MMP-1, leading to alterations in the extracellular matrix and consequent photoaging. Some plant components, renowned for their UV-absorbing and antioxidative properties, show potential for mitigating photoaging by reducing UV-B-induced MMP levels. In this context, we explored the inhibitory effects of Clerodendrum trichotomum extract (CTE) on UV-B-induced skin damage.

Methods: The mechanism of CTE was predicted using network pharmacology approach. Also, antiaging efficacy was evaluated by mouse model and cellular system using human epidermal keratinocytes (HEKa), including its modulation of mitogen-activated protein kinase (MAPK) signaling pathways.

Results: CTE effectively counters UV-B-induced skin damage, as evidenced by the suppression of MMP-9 and MMP-1 expression in mice. We found that each fraction and chemical constituents of CTE suppressed UV-B-induced MMP-1 secretion in HEKa cells.

Conclusion: CTE inhibits UV-B-induced skin aging by partially suppressing MMP-1 and MMP-9 secretion via the modulation of MAPK signaling pathways.

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.