从混乱到清晰？抗生素相关性腹泻中有效益生菌的探索。

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2024-10-21 eCollection Date: 2024-11-01 DOI:10.1093/ofid/ofae616

Krishna Rao, Kevin W Garey

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引用次数: 0

摘要

抗生素相关性腹泻（AAD）经常使感染治疗变得复杂。最近的一项随机、双盲、安慰剂对照试验对一种专有益生菌混合物进行了测试，发现它能将 AAD 的发生率降低 16%。这对患者来说令人鼓舞，但益生菌治疗 AAD 和其他疾病的未来进展取决于菌株选择的透明度、临床前机理研究指导下的益生菌设计以及严格的人体研究。

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From Chaos to Clarity? The Quest for Effective Probiotics in Antibiotic-Associated Diarrhea.

Antibiotic-associated diarrhea (AAD) frequently complicates treatment of infections. A recent randomized, double-blind, placebo-controlled trial tested a proprietary probiotic mixture and found that it reduced the incidence of AAD by 16%. This is encouraging for patients, but future progress on probiotics for AAD and other conditions depends on transparency around strain selection, probiotic design guided by preclinical mechanistic studies, and rigorously conducted human studies.

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.