Rhipicephalus simus蜱:噬血病毒的新宿主。

IF 2.1 3区 医学 Q2 PARASITOLOGY
Samuel Munalula Munjita, Benjamin Mubemba, John Tembo, Mathew Bates, Sody Munsaka
{"title":"Rhipicephalus simus蜱:噬血病毒的新宿主。","authors":"Samuel Munalula Munjita, Benjamin Mubemba, John Tembo, Mathew Bates, Sody Munsaka","doi":"10.1017/S0031182024001033","DOIUrl":null,"url":null,"abstract":"<p><p>Ticks are widespread arthropods that transmit microorganisms of veterinary and medical significance to vertebrates, including humans. <i>Rhipicephalus simus</i>, an ixodid tick frequently infesting and feeding on humans, may play a crucial role in transmitting infectious agents across species. Despite the known association of many <i>Rhipicephalus</i> ticks with phleboviruses, information on <i>R. simus</i> is lacking. During a study in a riverine area in Lusaka Zambia, ten <i>R. simus</i> ticks were incidentally collected from the grass and bushes and subjected to metagenomic next generation sequencing (mNGS) in 2 pools of 5. Analysis detected a diverse microbial profile, including bacteria 82% (32/39), fungi 15.4% (6/39), and viruses 2.6% (1/39). Notably, viral sequence LSK-ZM-102022 exhibited similarity to tick phleboviruses, sharing 74.92% nucleotide identity in the RdRp gene and 72% in the NP gene with tick-borne phlebovirus (TBPV) from Greece and Romania, respectively. Its RNA-dependent RNA polymerase (RdRp) encoding region carried conserved RdRp and endonuclease domains characteristic of phenuiviridae viruses. Phylogenetic analysis positioned LSK-ZM-102022 in a distinct but lone lineage within tick phleboviruses basal to known species like brown dog tick phlebovirus and phlebovirus Antigone. Pair-wise genetic distance analysis revealed similar findings. This study emphasizes the urgency of further research on the ecology, transmission dynamics, and pathogenic potential of LSK-ZM-102022 and related TBPVs, crucial for local and global preparedness against emerging tick-borne diseases.</p>","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"1-9"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>Rhipicephalus simus</i> ticks: new hosts for phleboviruses.\",\"authors\":\"Samuel Munalula Munjita, Benjamin Mubemba, John Tembo, Mathew Bates, Sody Munsaka\",\"doi\":\"10.1017/S0031182024001033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ticks are widespread arthropods that transmit microorganisms of veterinary and medical significance to vertebrates, including humans. <i>Rhipicephalus simus</i>, an ixodid tick frequently infesting and feeding on humans, may play a crucial role in transmitting infectious agents across species. Despite the known association of many <i>Rhipicephalus</i> ticks with phleboviruses, information on <i>R. simus</i> is lacking. During a study in a riverine area in Lusaka Zambia, ten <i>R. simus</i> ticks were incidentally collected from the grass and bushes and subjected to metagenomic next generation sequencing (mNGS) in 2 pools of 5. Analysis detected a diverse microbial profile, including bacteria 82% (32/39), fungi 15.4% (6/39), and viruses 2.6% (1/39). Notably, viral sequence LSK-ZM-102022 exhibited similarity to tick phleboviruses, sharing 74.92% nucleotide identity in the RdRp gene and 72% in the NP gene with tick-borne phlebovirus (TBPV) from Greece and Romania, respectively. Its RNA-dependent RNA polymerase (RdRp) encoding region carried conserved RdRp and endonuclease domains characteristic of phenuiviridae viruses. Phylogenetic analysis positioned LSK-ZM-102022 in a distinct but lone lineage within tick phleboviruses basal to known species like brown dog tick phlebovirus and phlebovirus Antigone. Pair-wise genetic distance analysis revealed similar findings. This study emphasizes the urgency of further research on the ecology, transmission dynamics, and pathogenic potential of LSK-ZM-102022 and related TBPVs, crucial for local and global preparedness against emerging tick-borne diseases.</p>\",\"PeriodicalId\":19967,\"journal\":{\"name\":\"Parasitology\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parasitology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/S0031182024001033\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0031182024001033","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

蜱虫是一种广泛分布的节肢动物,可向包括人类在内的脊椎动物传播具有兽医和医学意义的微生物。Rhipicephalus simus 是一种经常侵扰人类并以人类为食的伊科蜱,可能在跨物种传播传染性病原体方面扮演着至关重要的角色。尽管已知许多 Rhipicephalus 蜱与噬螨病毒有关,但有关 R. simus 的信息却很缺乏。在赞比亚卢萨卡的一个沿河地区进行的一项研究中,偶然从草丛和灌木丛中采集了 10 只 R. simus蜱虫,并对 2 个 5 只蜱虫池中的蜱虫进行了元基因组新一代测序(mNGS)。分析检测到了多种微生物特征,包括细菌 82%(32/39)、真菌 15.4%(6/39)和病毒 2.6%(1/39)。值得注意的是,病毒序列 LSK-ZM-102022 与蜱噬病毒表现出相似性,与希腊和罗马尼亚的蜱噬病毒(TBPV)的 RdRp 基因和 NP 基因的核苷酸相同度分别为 74.92% 和 72%。其 RNA 依赖性 RNA 聚合酶(RdRp)编码区含有苯病毒科病毒特有的保守的 RdRp 和内切酶结构域。系统进化分析将 LSK-ZM-102022 定位于蜱噬病毒中一个独特但孤独的系,与棕狗蜱噬病毒和噬病毒 Antigone 等已知物种相邻。配对遗传距离分析也发现了类似的结果。这项研究强调了进一步研究 LSK-ZM-102022 和相关 TBPV 的生态学、传播动力学和致病潜力的紧迫性,这对于地方和全球防范新出现的蜱传疾病至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rhipicephalus simus ticks: new hosts for phleboviruses.

Ticks are widespread arthropods that transmit microorganisms of veterinary and medical significance to vertebrates, including humans. Rhipicephalus simus, an ixodid tick frequently infesting and feeding on humans, may play a crucial role in transmitting infectious agents across species. Despite the known association of many Rhipicephalus ticks with phleboviruses, information on R. simus is lacking. During a study in a riverine area in Lusaka Zambia, ten R. simus ticks were incidentally collected from the grass and bushes and subjected to metagenomic next generation sequencing (mNGS) in 2 pools of 5. Analysis detected a diverse microbial profile, including bacteria 82% (32/39), fungi 15.4% (6/39), and viruses 2.6% (1/39). Notably, viral sequence LSK-ZM-102022 exhibited similarity to tick phleboviruses, sharing 74.92% nucleotide identity in the RdRp gene and 72% in the NP gene with tick-borne phlebovirus (TBPV) from Greece and Romania, respectively. Its RNA-dependent RNA polymerase (RdRp) encoding region carried conserved RdRp and endonuclease domains characteristic of phenuiviridae viruses. Phylogenetic analysis positioned LSK-ZM-102022 in a distinct but lone lineage within tick phleboviruses basal to known species like brown dog tick phlebovirus and phlebovirus Antigone. Pair-wise genetic distance analysis revealed similar findings. This study emphasizes the urgency of further research on the ecology, transmission dynamics, and pathogenic potential of LSK-ZM-102022 and related TBPVs, crucial for local and global preparedness against emerging tick-borne diseases.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Parasitology
Parasitology 医学-寄生虫学
CiteScore
4.80
自引率
4.20%
发文量
280
审稿时长
3-8 weeks
期刊介绍: Parasitology is an important specialist journal covering the latest advances in the subject. It publishes original research and review papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in parasite biochemistry, molecular biology and genetics, ecology and epidemiology in the context of the biological, medical and veterinary sciences. Included in the subscription price are two special issues which contain reviews of current hot topics, one of which is the proceedings of the annual Symposia of the British Society for Parasitology, while the second, covering areas of significant topical interest, is commissioned by the editors and the editorial board.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信