印度城市糖尿病视网膜病变的发病率和进展:Sankara Nethralaya 糖尿病视网膜病变流行病学和分子遗传学研究,15 年随访。

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Keerthana Raghu, Janani Surya R, Padmaja Kumari Rani, Tarun Sharma, Rajiv Raman
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引用次数: 0

摘要

目的:评估印度人口中糖尿病视网膜病变(DR)15 年的发病率和进展情况,并确定风险因素:方法:在对 1425 名受试者进行的横断面研究中,有 911 人参加了为期 4 年的随访。在这 911 名参与者中,有 140 人返回进行 15 年随访,基线检查在 2003 年至 2006 年期间进行,随后的随访在 2007 年至 2011 年期间进行,目前的 15 年随访在 2018 年至 2021 年期间进行。在这140名参与者中,有112人在排除了眼底照片无法分级的个体后符合分析条件:任何糖尿病视网膜病变(DR)的 15 年发病率为 5%,轻度 NPDR 和中度 NPDR 分别为 1.57% 和 2.7%。增殖性糖尿病视网膜病变占 0.71%,而糖尿病黄斑水肿(DME)和危及视力的糖尿病视网膜病变(STDR)的发病率分别为 0.48% 和 1.10%。年龄标准化比率显示,年龄的增长与任何糖尿病视网膜病变和 STDR 的发生都有显著的关联。15年间,DR的进展包括7.5%的一步进展和1.75%的两步进展,而回归仅限于1.75%的一步回归。多元逻辑回归分析表明,糖尿病的基线病程、收缩压、HbA1c水平和贫血的存在会影响任何DR、DME和STDR的发病率。吸烟和较高的 HbA1c 被认为是导致 DR 一步进展的风险因素:这项研究为了解印度 2 型糖尿病患者中 DR 的长期发病率、进展和消退情况提供了重要依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence and Progression of Diabetic Retinopathy in Urban India: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study, 15yr Follow up.

Purpose: To evaluate the 15 year incidence and progression of Diabetic Retinopathy (DR) and identify risk factors among Indian population.Methods: From a cross-sectional study of 1425 subjects, 911 participants took part in the 4-year follow-up. Out of these 911 participants, 140 returned for the 15-year follow-up, with baseline examinations conducted between 2003 and 2006, and subsequent follow-ups occurring from 2007 to 2011 and the current 15-year follow-up from 2018 to 2021. Of the 140 participants, 112 were eligible for analysis after excluding individuals with ungradable fundus photographs.Results: The 15-year incidence of any diabetic retinopathy (DR) was 5%, with mild NPDR and moderate NPDR at 1.57% and 2.7%, respectively. Proliferative DR was observed in 0.71% of cases, while diabetic macular edema (DME) and sight-threatening diabetic retinopathy (STDR) rates were 0.48% and 1.10%, respectively. Age-standardized rates revealed a significant association with increasing age and incident any DR and STDR. DR progression over 15 years included 7.5% one-step and 1.75% two-step progressions, while regression was limited to 1.75% one-step regression. Multiple logistic regression analyses revealed that baseline duration of diabetes, systolic blood pressure, HbA1c levels, and the presence of anemia influenced the incidence of any DR, DME, and STDR. Smoking and higher HbA1c were identified as risk factors for one-step progression of DR.Conclusion: This study provides crucial insights into the long-term incidence, progression, and regression of DR among individuals with Type 2 diabetes in India.

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来源期刊
Ophthalmic epidemiology
Ophthalmic epidemiology 医学-眼科学
CiteScore
3.70
自引率
5.60%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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