Ran Chang, Limin Liao, Huafang Jing, Yi Gao, Siyu Zhang, Yue Wang, Juan Wu
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Independent sample t tests were employed to compare general characteristics and VUDS parameters between groups. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive capability of UUT damage.</p><p><strong>Results: </strong>The study comprised 132 patients (86 males and 46 females) with an average NB duration of 7.37 ± 9.37 years (range: 0.2-44 years). UUT damage was present in 40.91% (n = 54) of patients. Significant differences (p < 0.05) were observed between the UUT damage and normal groups in terms of the duration of LUTS (9.98 ± 10.52 vs. 4.83 ± 7.32 years), creatinine levels (135.58 ± 110.51 vs. 57.66 ± 12.26 μmol/L), and BDI (103.28 ± 71.6 vs. 19.23 ± 15.03%). No significant differences were noted in age, bladder volume, or residual urine between the groups (p > 0.05). The AUC for the duration of LUTS, creatinine, and BDI were 0.691, 0.786, and 0.908, respectively, with a BDI Yoden index of 77%.</p><p><strong>Conclusion: </strong>Long-term LUTS, elevated creatinine levels, and high BDI are associated with UUT damage. BDI demonstrates high sensitivity and specificity in diagnosing UUT damage, outperforming creatinine levels and NB duration. Patients with BDI values exceeding 77% are at a heightened risk of UUT damage. BDI facilitates quantitative evaluation of cystography and preliminary evaluation upper and lower urinary tract function in NB patients. Further research is warranted to validate BDI's feasibility in quantifying cystography and diagnosing UUT damage.</p><p><strong>Trial registration: </strong>This study is retrospective and does not require clinical trial registration.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"103-108"},"PeriodicalIF":1.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prediction Value of Bladder Deformity Index for Upper Urinary Tract Damage in Patients With Neurogenic Bladder.\",\"authors\":\"Ran Chang, Limin Liao, Huafang Jing, Yi Gao, Siyu Zhang, Yue Wang, Juan Wu\",\"doi\":\"10.1002/nau.25610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>This study aimed to assess the predictive value of the Bladder Deformity Index (BDI) in determining upper urinary tract (UUT) damage among patients with neurogenic bladder (NB).</p><p><strong>Methods: </strong>Clinical data of 132 NB patients admitted to the China Rehabilitation Research Center between January 2018 and December 2023 were retrospectively analyzed. Patients were categorized into UUT damage and normal UUT function groups based on the MRU and ultrasound grading systems for hydronephrosis, patients with the grade greater than or equal to I degree were considered to have UUTD. Patient demographics, biochemical parameters, and video-urodynamics (VUDS) findings were collected, and BDI was calculated. Independent sample t tests were employed to compare general characteristics and VUDS parameters between groups. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive capability of UUT damage.</p><p><strong>Results: </strong>The study comprised 132 patients (86 males and 46 females) with an average NB duration of 7.37 ± 9.37 years (range: 0.2-44 years). UUT damage was present in 40.91% (n = 54) of patients. Significant differences (p < 0.05) were observed between the UUT damage and normal groups in terms of the duration of LUTS (9.98 ± 10.52 vs. 4.83 ± 7.32 years), creatinine levels (135.58 ± 110.51 vs. 57.66 ± 12.26 μmol/L), and BDI (103.28 ± 71.6 vs. 19.23 ± 15.03%). No significant differences were noted in age, bladder volume, or residual urine between the groups (p > 0.05). The AUC for the duration of LUTS, creatinine, and BDI were 0.691, 0.786, and 0.908, respectively, with a BDI Yoden index of 77%.</p><p><strong>Conclusion: </strong>Long-term LUTS, elevated creatinine levels, and high BDI are associated with UUT damage. BDI demonstrates high sensitivity and specificity in diagnosing UUT damage, outperforming creatinine levels and NB duration. Patients with BDI values exceeding 77% are at a heightened risk of UUT damage. BDI facilitates quantitative evaluation of cystography and preliminary evaluation upper and lower urinary tract function in NB patients. 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引用次数: 0
摘要
目的：本研究旨在评估膀胱畸形指数（BDI）在判断神经源性膀胱（NB）患者上尿路（UUT）损伤方面的预测价值：回顾性分析2018年1月至2023年12月期间中国康复研究中心收治的132例NB患者的临床数据。根据MRU和超声肾积水分级系统将患者分为UUT损伤组和UUT功能正常组，分级大于或等于I度的患者被认为患有UUTD。收集患者的人口统计学资料、生化参数和视频尿动力学（VUDS）检查结果，并计算 BDI。采用独立样本 t 检验比较组间一般特征和 VUDS 参数。利用受体操作特征曲线（ROC）评估 UUT 损伤的预测能力：该研究包括 132 名患者（86 名男性和 46 名女性），平均 NB 病程为 7.37 ± 9.37 年（范围：0.2-44 年）。40.91%的患者（n = 54）存在 UUT 损伤。差异显著（P 0.05）。LUTS持续时间、肌酐和BDI的AUC分别为0.691、0.786和0.908，BDI约登指数为77%：结论：长期尿失禁、肌酐水平升高和 BDI 偏高与 UUT 损伤有关。BDI 在诊断 UUT 损伤方面具有较高的灵敏度和特异性，优于肌酐水平和 NB 持续时间。BDI 值超过 77% 的患者发生 UUT 损伤的风险较高。BDI 有助于对膀胱造影进行定量评估，并初步评估 NB 患者的上下尿路功能。需要进一步研究验证 BDI 在量化膀胱造影和诊断 UUT 损伤方面的可行性：本研究为回顾性研究，无需进行临床试验注册。
Prediction Value of Bladder Deformity Index for Upper Urinary Tract Damage in Patients With Neurogenic Bladder.
Aim: This study aimed to assess the predictive value of the Bladder Deformity Index (BDI) in determining upper urinary tract (UUT) damage among patients with neurogenic bladder (NB).
Methods: Clinical data of 132 NB patients admitted to the China Rehabilitation Research Center between January 2018 and December 2023 were retrospectively analyzed. Patients were categorized into UUT damage and normal UUT function groups based on the MRU and ultrasound grading systems for hydronephrosis, patients with the grade greater than or equal to I degree were considered to have UUTD. Patient demographics, biochemical parameters, and video-urodynamics (VUDS) findings were collected, and BDI was calculated. Independent sample t tests were employed to compare general characteristics and VUDS parameters between groups. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive capability of UUT damage.
Results: The study comprised 132 patients (86 males and 46 females) with an average NB duration of 7.37 ± 9.37 years (range: 0.2-44 years). UUT damage was present in 40.91% (n = 54) of patients. Significant differences (p < 0.05) were observed between the UUT damage and normal groups in terms of the duration of LUTS (9.98 ± 10.52 vs. 4.83 ± 7.32 years), creatinine levels (135.58 ± 110.51 vs. 57.66 ± 12.26 μmol/L), and BDI (103.28 ± 71.6 vs. 19.23 ± 15.03%). No significant differences were noted in age, bladder volume, or residual urine between the groups (p > 0.05). The AUC for the duration of LUTS, creatinine, and BDI were 0.691, 0.786, and 0.908, respectively, with a BDI Yoden index of 77%.
Conclusion: Long-term LUTS, elevated creatinine levels, and high BDI are associated with UUT damage. BDI demonstrates high sensitivity and specificity in diagnosing UUT damage, outperforming creatinine levels and NB duration. Patients with BDI values exceeding 77% are at a heightened risk of UUT damage. BDI facilitates quantitative evaluation of cystography and preliminary evaluation upper and lower urinary tract function in NB patients. Further research is warranted to validate BDI's feasibility in quantifying cystography and diagnosing UUT damage.
Trial registration: This study is retrospective and does not require clinical trial registration.
期刊介绍：
Neurourology and Urodynamics welcomes original scientific contributions from all parts of the world on topics related to urinary tract function, urinary and fecal continence and pelvic floor function.
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