Maorong Qin, Kun Xu, Zhuo Chen, Xiaojie Wen, Yifu Tang, Yangyu Gao, Hao Zhang, Xingming Ma
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Heterogeneity was evaluated using the I2 statistic. A randomized controlled trial, cohort studies, and retrospective studies in which vitamin C supplementation was supplemented as monotherapy or in combination, compared with placebo, no treatment, or other standard treatment without vitamin C were included.</p><p><strong>Data analysis: </strong>After screening, 22 studies, with a total of 6831 patients, were selected for assessment. Odds ratios (ORs) with 95% CIs were calculated using fixed- and random-effects models. The meta-analysis showed significant effects of vitamin C on alleviating clinical outcomes in patients with COVID-19 (OR = 0.76, 95% CI = 0.65-0.89, P = .0007) but no shortening of the length of hospitalization (OR = 1.16, 95% CI = -0.13-2.44, P = .08) compared with the control group. 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引用次数: 0
摘要
背景：维生素C已被用作一种重要的抗氧化剂，以减轻2019年冠状病毒病（COVID-19）患者与肺炎和急性呼吸窘迫综合征相关的炎症反应，但其对临床结果的影响仍存在争议且尚无定论：本研究旨在进行荟萃分析和系统综述，评估补充维生素 C 对住院患者 COVID-19 严重程度的影响：在Web of Science、Embase、Cochrane Library、PubMed、CNKI、CSTJ、Wan fang和CBM数据库中检索了2020年1月至2023年12月期间符合纳入标准的出版物：使用Review Manager软件对一项以上研究的结果进行荟萃分析。使用 I2 统计量评估异质性。纳入的研究包括随机对照试验、队列研究和回顾性研究，在这些研究中，补充维生素 C 可作为单一疗法或联合疗法，并与安慰剂、不治疗或其他不含维生素 C 的标准疗法进行比较：经过筛选，共有 22 项研究（共 6831 名患者）被纳入评估范围。采用固定效应和随机效应模型计算了患病率比（ORs）和 95% CIs。荟萃分析表明，与对照组相比，维生素 C 对缓解 COVID-19 患者的临床症状有显著效果（OR = 0.76，95% CI = 0.65-0.89，P = .0007），但没有缩短住院时间（OR = 1.16，95% CI = -0.13-2.44，P = .08）。值得注意的是，维生素 C 补充剂能显著降低 COVID-19 患者的死亡风险（OR = 0.64，95% CI = 0.51-0.80，P = .0001）和严重程度的发生率（OR = 0.59，95% CI = 0.43-0.80，P = .0006）：结论：研究结果表明，维生素C补充剂可能对COVID-19患者的临床预后以及降低严重程度和死亡率有好处，但还需要更多的临床随机对照试验来评估维生素C在治疗COVID-19中的作用：系统综述注册：PROSPERO 注册号CRD42023491517。
Effects of Vitamin C Supplements on Clinical Outcomes and Hospitalization Duration for Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis.
Context: Vitamin C has been used as an essential antioxidant to reduce the inflammatory response associated with pneumonia and acute respiratory distress syndrome in patients with the 2019 coronavirus disease (COVID-19), but its effect on clinical outcomes remains controversial and inconclusive.
Objective: The purpose of this study was to conduct a meta-analysis and systematic review to assess the effects of vitamin C supplementation on the severity of COVID-19 in hospitalized patients.
Data sources: Web of Science, Embase, Cochrane Library, PubMed, CNKI, CSTJ, Wan fang, and CBM databases were searched for publications between January 2020 and December 2023 that met the inclusion criteria.
Data extraction: The meta-analyses of outcomes in more than one study were performed using Review Manager software. Heterogeneity was evaluated using the I2 statistic. A randomized controlled trial, cohort studies, and retrospective studies in which vitamin C supplementation was supplemented as monotherapy or in combination, compared with placebo, no treatment, or other standard treatment without vitamin C were included.
Data analysis: After screening, 22 studies, with a total of 6831 patients, were selected for assessment. Odds ratios (ORs) with 95% CIs were calculated using fixed- and random-effects models. The meta-analysis showed significant effects of vitamin C on alleviating clinical outcomes in patients with COVID-19 (OR = 0.76, 95% CI = 0.65-0.89, P = .0007) but no shortening of the length of hospitalization (OR = 1.16, 95% CI = -0.13-2.44, P = .08) compared with the control group. Notably, vitamin C supplements significantly reduced the mortality risk (OR = 0.64, 95% CI = 0.51-0.80, P = .0001) and the incidence of severity (OR = 0.59, 95% CI = 0.43-0.80, P = .0006) in COVID-19 patients.
Conclusion: The findings suggest that vitamin C supplements may have a beneficial effect on clinical outcomes, as well as reducing severity and mortality in COVID-19 patients, but more clinical randomized controlled trials are needed to evaluate the role of vitamin C in treating COVID-19.
期刊介绍：
Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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