Andres E Carrillo, Petros C Dinas, Argyro Krase, Eleni Nintou, Alexandros Georgakopoulos, Marinos Metaxas, Edward J Ryan, Maria Vliora, Panagiotis Georgoulias, Sofia Chatziioannou, Andreas D Flouris
{"title":"具有不同冷诱导棕色脂肪组织活化水平的成年男性的膳食摄入量相似。","authors":"Andres E Carrillo, Petros C Dinas, Argyro Krase, Eleni Nintou, Alexandros Georgakopoulos, Marinos Metaxas, Edward J Ryan, Maria Vliora, Panagiotis Georgoulias, Sofia Chatziioannou, Andreas D Flouris","doi":"10.3390/nu16213697","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objectives: </strong>Brown adipose tissue (BAT) activation has important metabolic health implications, yet the relationship between habitual dietary intake and BAT activity in humans remains to be fully understood.</p><p><strong>Methods: </strong>We compared dietary intake among adult men with (BAT<sub>positive</sub>, age: 34.8 ± 5.4 years, BMI: 28.2 ± 5.3 kg/m<sup>2</sup>, <i>n</i> = 12) and without (BAT<sub>negative</sub>, age: 39.1 ± 4.1 years, BMI: 31.1 ± 6.7 kg/m<sup>2</sup>, <i>n</i> = 11) cold-induced BAT activation. Activation of BAT was measured immediately following 2 h of cold exposure using <sup>18</sup>F fluorodeoxyglucose positron emission tomography and computed tomography reported as maximum standardized uptake (SUV<sub>max</sub>). Participants categorized as BAT<sub>positive</sub> had an SUV<sub>max</sub> > 1.5 g/mL that was normalized to lean body mass (SUV<sub>lean</sub>) for analysis. Shivering intensity was recorded every 15 min during cold exposure and dietary intake was estimated from 7 consecutive 24 h dietary recalls.</p><p><strong>Results: </strong>The BAT<sub>negative</sub> group was significantly older than the BAT<sub>positive</sub> group (<i>p</i> = 0.046). Although BAT<sub>negative</sub> participants consumed an average of 281.2 kcal/day more than BAT<sub>positive</sub>, there were no significant differences in dietary intake between groups (<i>p</i> ≥ 0.202). Further, no statistically significant associations between SUV<sub>lean</sub> and dietary intake among BAT<sub>positive</sub> participants were observed (<i>p</i> ≥ 0.175). Participants who shivered (<i>n</i> = 9) during cold exposure tended to be shorter (<i>p</i> = 0.056) and have a lower waist-to-hip ratio (<i>p</i> = 0.097) but did not differ in dietary intake (<i>p</i> ≥ 0.204) or BAT activity (<i>p</i> = 0.964) when compared to the non-shivering (<i>n</i> = 11) group.</p><p><strong>Conclusions: </strong>Our results indicate that BAT activity and shivering during cold exposure are more strongly related to variables such as age and body size or composition rather than habitual dietary intake. We conclude that habitual dietary intake likely has a negligible influence on BAT activity among adult men.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"16 21","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547816/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dietary Intake Is Similar Among Adult Men with Different Levels of Cold-Induced Brown Adipose Tissue Activation.\",\"authors\":\"Andres E Carrillo, Petros C Dinas, Argyro Krase, Eleni Nintou, Alexandros Georgakopoulos, Marinos Metaxas, Edward J Ryan, Maria Vliora, Panagiotis Georgoulias, Sofia Chatziioannou, Andreas D Flouris\",\"doi\":\"10.3390/nu16213697\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/objectives: </strong>Brown adipose tissue (BAT) activation has important metabolic health implications, yet the relationship between habitual dietary intake and BAT activity in humans remains to be fully understood.</p><p><strong>Methods: </strong>We compared dietary intake among adult men with (BAT<sub>positive</sub>, age: 34.8 ± 5.4 years, BMI: 28.2 ± 5.3 kg/m<sup>2</sup>, <i>n</i> = 12) and without (BAT<sub>negative</sub>, age: 39.1 ± 4.1 years, BMI: 31.1 ± 6.7 kg/m<sup>2</sup>, <i>n</i> = 11) cold-induced BAT activation. Activation of BAT was measured immediately following 2 h of cold exposure using <sup>18</sup>F fluorodeoxyglucose positron emission tomography and computed tomography reported as maximum standardized uptake (SUV<sub>max</sub>). Participants categorized as BAT<sub>positive</sub> had an SUV<sub>max</sub> > 1.5 g/mL that was normalized to lean body mass (SUV<sub>lean</sub>) for analysis. Shivering intensity was recorded every 15 min during cold exposure and dietary intake was estimated from 7 consecutive 24 h dietary recalls.</p><p><strong>Results: </strong>The BAT<sub>negative</sub> group was significantly older than the BAT<sub>positive</sub> group (<i>p</i> = 0.046). Although BAT<sub>negative</sub> participants consumed an average of 281.2 kcal/day more than BAT<sub>positive</sub>, there were no significant differences in dietary intake between groups (<i>p</i> ≥ 0.202). Further, no statistically significant associations between SUV<sub>lean</sub> and dietary intake among BAT<sub>positive</sub> participants were observed (<i>p</i> ≥ 0.175). Participants who shivered (<i>n</i> = 9) during cold exposure tended to be shorter (<i>p</i> = 0.056) and have a lower waist-to-hip ratio (<i>p</i> = 0.097) but did not differ in dietary intake (<i>p</i> ≥ 0.204) or BAT activity (<i>p</i> = 0.964) when compared to the non-shivering (<i>n</i> = 11) group.</p><p><strong>Conclusions: </strong>Our results indicate that BAT activity and shivering during cold exposure are more strongly related to variables such as age and body size or composition rather than habitual dietary intake. We conclude that habitual dietary intake likely has a negligible influence on BAT activity among adult men.</p>\",\"PeriodicalId\":19486,\"journal\":{\"name\":\"Nutrients\",\"volume\":\"16 21\",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547816/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrients\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/nu16213697\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrients","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/nu16213697","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Dietary Intake Is Similar Among Adult Men with Different Levels of Cold-Induced Brown Adipose Tissue Activation.
Background/objectives: Brown adipose tissue (BAT) activation has important metabolic health implications, yet the relationship between habitual dietary intake and BAT activity in humans remains to be fully understood.
Methods: We compared dietary intake among adult men with (BATpositive, age: 34.8 ± 5.4 years, BMI: 28.2 ± 5.3 kg/m2, n = 12) and without (BATnegative, age: 39.1 ± 4.1 years, BMI: 31.1 ± 6.7 kg/m2, n = 11) cold-induced BAT activation. Activation of BAT was measured immediately following 2 h of cold exposure using 18F fluorodeoxyglucose positron emission tomography and computed tomography reported as maximum standardized uptake (SUVmax). Participants categorized as BATpositive had an SUVmax > 1.5 g/mL that was normalized to lean body mass (SUVlean) for analysis. Shivering intensity was recorded every 15 min during cold exposure and dietary intake was estimated from 7 consecutive 24 h dietary recalls.
Results: The BATnegative group was significantly older than the BATpositive group (p = 0.046). Although BATnegative participants consumed an average of 281.2 kcal/day more than BATpositive, there were no significant differences in dietary intake between groups (p ≥ 0.202). Further, no statistically significant associations between SUVlean and dietary intake among BATpositive participants were observed (p ≥ 0.175). Participants who shivered (n = 9) during cold exposure tended to be shorter (p = 0.056) and have a lower waist-to-hip ratio (p = 0.097) but did not differ in dietary intake (p ≥ 0.204) or BAT activity (p = 0.964) when compared to the non-shivering (n = 11) group.
Conclusions: Our results indicate that BAT activity and shivering during cold exposure are more strongly related to variables such as age and body size or composition rather than habitual dietary intake. We conclude that habitual dietary intake likely has a negligible influence on BAT activity among adult men.
期刊介绍：
Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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