一种来自海洋链霉菌 SYPHU 0002 的新型苯并二恶茂衍生物。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-11-09 DOI:10.1080/14786419.2024.2425058

Pengyun Mou, Yuan Peng, Bangyan Zhang, Pengze Wang, Xianpu Ni, Huanzhang Xia

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引用次数: 0

摘要

一种新的苯并二恶茂衍生物 1,3-苯并二恶茂-2-酮-4-N-甲基甲酰胺（1），两种新的天然产物 N-（氨基羰基）-2,3-二甲氧基苯甲酰胺（2）和 2,3-二甲氧基-N-甲基苯甲酰胺（3），以及 8 种已知化合物（4-11），都是从海洋链霉菌 SYPHU 0002 中分离出来的。通过全面的光谱分析，包括 HRESIMS、一维和二维核磁共振，确定了化合物 1-11 的结构。化合物 9 对枯草芽孢杆菌具有微弱的抗菌活性，其 MIC 值为 64 μg mL-1。

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A new benzodioxole derivative from the marine-derived Streptomyces sp. SYPHU 0002.

a new benzodioxole derivative 1,3-benzodioxole-2-one-4-N-methylcarboxylamide (1), two new natural products N-(aminocarbonyl)-2,3-dimethoxy-benzamide (2) and 2,3-dimethoxy-N-methylbenzamide (3), along with eight known compounds (4-11), were isolated from the marine-derived Streptomyces sp. SYPHU 0002. The structures of compounds 1-11 were determined through comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR. Compound 9 showed weak antibacterial activity against Bacillus pumilus with the MIC value of 64 μg mL^-1.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.