疫苗接种是小儿多发性硬化症的风险因素：一项回顾性病例对照研究的启示。

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-11-14 DOI:10.1177/13524585241297003

Sonia Darvishi, Ewan Donnachie, Christiane Gasperi, Alexander Hapfelmeier, Bernhard Hemmer

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引用次数: 0

摘要

本研究利用德国门诊报销数据评估了小儿多发性硬化症与确诊前 5 年内接种疫苗之间的关系。研究采用逻辑回归和泊松回归对 9-17 岁的多发性硬化症患儿（n = 346）进行了分析。对照组包括患有克罗恩病、银屑病和无自身免疫性疾病的儿童。结果表明，接种疫苗与小儿多发性硬化症之间存在负相关，没有发现显著的风险。这种负相关关系在敏感性和临床孤立综合征分析中是一致的。总体而言，研究结果不支持接种疫苗是小儿多发性硬化症风险因素的假设。

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Vaccination as a risk factor for pediatric multiple sclerosis: Insights from a retrospective case-control study.

This study evaluated the association between pediatric multiple sclerosis and vaccinations within 5 years before diagnosis using German ambulatory claims data. Children with multiple sclerosis (n = 346) aged 9-17 were analyzed with logistic and Poisson regression. Control groups included children with Crohn's disease, psoriasis, and no autoimmune diseases. The results indicated a negative association between vaccinations and pediatric multiple sclerosis, with no significant risk identified. This negative relationship was consistent in sensitivity and clinically isolated syndrome analyses. Overall, the study's findings do not support the hypothesis that vaccination is a risk factor for pediatric multiple sclerosis.

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585