一大批反复呼吸道乳头状瘤病患者中发育不良和恶性肿瘤的患病率和风险因素。

IF 0.8 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2025-06-01 DOI:10.1017/S0022215124002172

Bhargavi Chandrasekar, Alexandra Bell, Andrew Kinshuck

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引用次数: 0

摘要

目的：本研究的目的是评估复发性呼吸道乳头状瘤病患者的不典型增生和乳头状瘤外癌的发生率，并评估任何危险因素。方法：在单中心进行一项为期15年的回顾性观察队列研究。从临床记录中提取患者人口统计学、治疗史和病理结果的数据。结果：123例患者中，9例为青少年复发性呼吸道乳头状瘤病，114例为成人复发性呼吸道乳头状瘤病。13例（11%）成人发病的复发性呼吸道乳头状瘤病患者患有发育不良，1例进展为乳头状瘤外癌。与没有发育不良的患者相比，有发育不良证据的患者平均发病年龄更大（49岁vs 39岁，p = 0.03）。结论：复发性呼吸道乳头状瘤病发病年龄较大是不典型增生的唯一危险因素。性别、吸烟、声门下或气管受累性、手术次数和西多福韦不是本系列的预后因素。

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Prevalence and risk factors for dysplasia and malignancy in a large cohort of patients with recurrent respiratory papillomatosis.

Objectives: The aim of this study was to evaluate the rate of dysplasia and carcinoma-ex-papillomatosis in patients with recurrent respiratory papillomatosis and assess for any risk factors.

Methods: A 15-year retrospective observational cohort study was performed from a single centre. Data on patient demographics, treatment history and pathology results were extracted from clinical records.

Results: Of the 123 patients identified, nine had juvenile-onset recurrent respiratory papillomatosis and 114 had adult-onset recurrent respiratory papillomatosis. Thirteen (11 per cent) of patients with adult-onset recurrent respiratory papillomatosis had dysplasia, and one patient progressed to carcinoma-ex-papillomatosis. Patients with evidence of dysplasia had an average older age of disease onset compared to those without dysplasia (49 years vs 39 years, p = 0.03).

Conclusion: An older age of recurrent respiratory papillomatosis onset was the only risk factor for dysplasia. Gender, tobacco use, subglottic or tracheal involvement, number of surgeries and cidofovir were not prognostic factors in this series.

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.