合成负载头孢克肟的 PCL/HPMC 混合纳米颗粒：控释研究和体外抗菌评估。

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2024-11-12 DOI:10.1080/02652048.2024.2427292

Yashvi Naik, Hem N Naik, Jay Rai, Rushabh Shah, Smita Jauhari, Anand J Patel

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引用次数: 0

摘要

目的：为提高头孢克肟的疗效，解决给药部位浓度、剂量和时间等难题，本研究探讨了聚合物混合物对头孢克肟体外释放曲线的影响：方法：采用改良溶剂蒸发法制备头孢克肟负载纳米粒子，形成 W/O/W 双乳液。表征包括傅立叶变换红外光谱、ZETA电位、TGA、TEM和XRD，体外研究和动力学模型用于分析释放机制：结果：PH-4 纳米粒子配方（80:20 PCL/HPMC，0.5% PVA）的负载率达到 81%，无不良反应，30 天内的控释率为 84.66%±2.53。其理化性质稳定，体外抗菌测试显示，12 小时内对大肠杆菌的抑菌区为 27.4 ± 2.12 mm，对金黄色葡萄球菌的抑菌区为 17.2 ± 2.23 mm：根据研究结果，所开发的含有 PCL/HPMC 的纳米颗粒系统证明了其作为头孢克肟等抗生素的控制给药方法的有效性和安全性。

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Synthesis of cefixime loaded PCL/HPMC blend nanoparticles: a controlled release study and in vitro anti-bacterial evaluation.

Aim: To enhance cefixime's effectiveness and address drug delivery challenges like concentration at the site, dose, and time, present study investigated the impact of polymer blends on cefixime's in vitro release profile.

Methods: Cefixime-loaded nanoparticles were prepared via a modified solvent evaporation method, forming a W/O/W double emulsion. Characterisation included FT-IR, zeta potential, TGA, TEM, and XRD, with in vitro studies and kinetic models used to analyse the release mechanism.

Results: The PH-4 nanoparticle formulation (80:20 PCL/HPMC, 0.5% PVA) achieved an 81% loading rate, no adverse effects, and a controlled release of 84.66%±2.53 over 30 days. It showed stable physicochemical properties, with in vitro antibacterial tests revealing inhibition zones of 27.4 ± 2.12 mm for E. coli and 17.2 ± 2.23 mm for S. aureus at 12 hours.

Conclusion: Based on the findings, developed nanoparticulate system containing PCL/HPMC demonstrates its efficacy and safety as a controlled drug delivery method for antibiotics like cefixime.

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.