{"title":"白细胞介素多态性对复发性妊娠失败风险的影响：系统回顾和元分析。","authors":"Praveen Kumar Chandra Sekar, Ramakrishnan Veerabathiran","doi":"10.4103/jhrs.jhrs_110_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Interleukin (IL) genes are essential for regulating the immune and inflammatory processes. Epidemiological studies suggest that polymorphisms in IL genes are associated with a higher risk of recurrent pregnancy loss (RPL).</p><p><strong>Objective: </strong>This study aimed to examine the association between RPL risk and IL gene polymorphisms.</p><p><strong>Materials and methods: </strong>A comprehensive search of the literature was conducted using PubMed, Google Scholar and Embase to identify relevant studies published until May 30, 2024. A total of 58 studies involving 13,696 participants (both RPL cases and controls) were included. Pooled odds ratios and 95% confidence intervals were calculated using fixed- or random-effects models, as appropriate, with ReviewManager version 5.4, Cochrane RoB Tool 2 and G*Power 3.1 software.</p><p><strong>Results: </strong>The meta-analysis revealed significant correlations between RPL risk and genetic variations in IL-1β (-511T > C), IL-6 (-174 G > C) and IL-10 (-1082 A > G and-592 C > A), with statistical significance set at <i>P</i> < 0.05. Ethnic subgroup analysis showed that IL-1β (-511T > C) and IL-10 (-592 C > A) variations were strongly associated with RPL risk in Asian populations.</p><p><strong>Interpretation: </strong>Our research suggests that genetic variations in IL-1β (-511T > C), IL-6 (-174 G > C) and IL-10 (-1082 A > G and-592 C > A) are associated with susceptibility to RPL.</p><p><strong>Limitation: </strong>Our meta-analysis concentrated exclusively on single-factor studies and did not consider potential confounding variables such as age, environmental influences and lifestyle, which could affect susceptibility to RPL. In addition, the lack of individual raw data prevented us from investigating gene-environment and gene-gene interactions or the influence of other polymorphisms and cytokines in our analysis.</p><p><strong>Protocol registration: </strong>http://www.osf.io/qhbva.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 3","pages":"142-157"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559354/pdf/","citationCount":"0","resultStr":"{\"title\":\"Influence of Interleukin Polymorphisms on the Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-analysis.\",\"authors\":\"Praveen Kumar Chandra Sekar, Ramakrishnan Veerabathiran\",\"doi\":\"10.4103/jhrs.jhrs_110_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Interleukin (IL) genes are essential for regulating the immune and inflammatory processes. Epidemiological studies suggest that polymorphisms in IL genes are associated with a higher risk of recurrent pregnancy loss (RPL).</p><p><strong>Objective: </strong>This study aimed to examine the association between RPL risk and IL gene polymorphisms.</p><p><strong>Materials and methods: </strong>A comprehensive search of the literature was conducted using PubMed, Google Scholar and Embase to identify relevant studies published until May 30, 2024. A total of 58 studies involving 13,696 participants (both RPL cases and controls) were included. Pooled odds ratios and 95% confidence intervals were calculated using fixed- or random-effects models, as appropriate, with ReviewManager version 5.4, Cochrane RoB Tool 2 and G*Power 3.1 software.</p><p><strong>Results: </strong>The meta-analysis revealed significant correlations between RPL risk and genetic variations in IL-1β (-511T > C), IL-6 (-174 G > C) and IL-10 (-1082 A > G and-592 C > A), with statistical significance set at <i>P</i> < 0.05. Ethnic subgroup analysis showed that IL-1β (-511T > C) and IL-10 (-592 C > A) variations were strongly associated with RPL risk in Asian populations.</p><p><strong>Interpretation: </strong>Our research suggests that genetic variations in IL-1β (-511T > C), IL-6 (-174 G > C) and IL-10 (-1082 A > G and-592 C > A) are associated with susceptibility to RPL.</p><p><strong>Limitation: </strong>Our meta-analysis concentrated exclusively on single-factor studies and did not consider potential confounding variables such as age, environmental influences and lifestyle, which could affect susceptibility to RPL. 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引用次数: 0
摘要
背景：白细胞介素（IL）基因对调节免疫和炎症过程至关重要。流行病学研究表明，IL 基因的多态性与较高的复发性妊娠损失（RPL）风险有关：本研究旨在探讨 RPL 风险与 IL 基因多态性之间的关联：使用 PubMed、Google Scholar 和 Embase 对文献进行了全面检索，以确定 2024 年 5 月 30 日之前发表的相关研究。共纳入了 58 项研究，涉及 13,696 名参与者（包括 RPL 病例和对照组）。利用ReviewManager 5.4版、Cochrane RoB Tool 2和G*Power 3.1软件，酌情使用固定效应或随机效应模型计算汇总的几率比和95%置信区间：荟萃分析显示，RPL风险与IL-1β（-511T > C）、IL-6（-174 G > C）和IL-10（-1082 A > G和-592 C > A）的遗传变异之间存在显著相关性，统计学显著性为P < 0.05。种族亚组分析显示，在亚洲人群中，IL-1β（-511T > C）和IL-10（-592 C > A）变异与RPL风险密切相关：我们的研究表明，IL-1β（-511T > C）、IL-6（-174 G > C）和IL-10（-1082 A > G和-592 C > A）的遗传变异与RPL的易感性有关：局限性：我们的荟萃分析完全集中于单因素研究，没有考虑年龄、环境影响和生活方式等可能影响 RPL 易感性的潜在混杂变量。此外，由于缺乏个体原始数据，我们无法在分析中研究基因与环境、基因与基因之间的相互作用或其他多态性和细胞因子的影响。协议注册：http://www.osf.io/qhbva。
Influence of Interleukin Polymorphisms on the Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-analysis.
Background: Interleukin (IL) genes are essential for regulating the immune and inflammatory processes. Epidemiological studies suggest that polymorphisms in IL genes are associated with a higher risk of recurrent pregnancy loss (RPL).
Objective: This study aimed to examine the association between RPL risk and IL gene polymorphisms.
Materials and methods: A comprehensive search of the literature was conducted using PubMed, Google Scholar and Embase to identify relevant studies published until May 30, 2024. A total of 58 studies involving 13,696 participants (both RPL cases and controls) were included. Pooled odds ratios and 95% confidence intervals were calculated using fixed- or random-effects models, as appropriate, with ReviewManager version 5.4, Cochrane RoB Tool 2 and G*Power 3.1 software.
Results: The meta-analysis revealed significant correlations between RPL risk and genetic variations in IL-1β (-511T > C), IL-6 (-174 G > C) and IL-10 (-1082 A > G and-592 C > A), with statistical significance set at P < 0.05. Ethnic subgroup analysis showed that IL-1β (-511T > C) and IL-10 (-592 C > A) variations were strongly associated with RPL risk in Asian populations.
Interpretation: Our research suggests that genetic variations in IL-1β (-511T > C), IL-6 (-174 G > C) and IL-10 (-1082 A > G and-592 C > A) are associated with susceptibility to RPL.
Limitation: Our meta-analysis concentrated exclusively on single-factor studies and did not consider potential confounding variables such as age, environmental influences and lifestyle, which could affect susceptibility to RPL. In addition, the lack of individual raw data prevented us from investigating gene-environment and gene-gene interactions or the influence of other polymorphisms and cytokines in our analysis.
期刊介绍：
The Journal of Human Reproductive Sciences (JHRS) (ISSN:0974-1208) a Quarterly peer-reviewed international journal is being launched in January 2008 under the auspices of Indian Society of Assisted Reproduction. The journal will cover all aspects human reproduction including Andrology, Assisted conception, Endocrinology, Physiology and Pathology, Implantation, Preimplantation Diagnosis, Preimplantation Genetic Diagnosis, Embryology as well as Ethical, Legal and Social issues. The journal will publish peer-reviewed original research papers, case reports, systematic reviews, meta-analysis, and debates.
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