阿尔茨海默病、路易体痴呆症和皮质基底综合征早期患者的 SBM 和 TBSS 分析。

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Geriatric Psychiatry and Neurology Pub Date : 2024-11-14 DOI:10.1177/08919887241302110

Alexandros Giannakis, Evrysthenis Vartholomatos, Loukas Astrakas, Emmanouil Anyfantis, Athina Tatsioni, Maria Argyropoulou, Spiridon Konitsiotis

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引用次数: 0

摘要

目的比较阿尔茨海默病（AD）、路易体痴呆（LBD）、皮质基底综合征（CBS）患者和健康对照组（HC）的灰质（GM）和白质（WM）变化：采用FreeSurfer图像分析方法对12名AD患者、15名LBD患者、10名CBS患者和10名HC患者的三维T1加权图像进行基于表面的形态测量（SBM）评估，并采用基于瓣膜的空间统计（TBSS）方法研究WM的微观结构：结果：与 HC 相比，AD 患者的额叶上部、额叶中部和内侧眶额皮层的皮质表面积和体积都有所减少。在TBSS中，与HC和LBD相比，AD患者在所有主要WM束中的分数各向异性、轴向扩散性均有所下降，而径向扩散性则有所上升。在SBM或TBSS分析中，各组间的其他比较结果均无差异：结论：研究结果表明，AD 患者的额叶 GM 早期结构发生了显著变化，同时 WM 也发生了早期改变。

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An SBM and TBSS Analysis in Early-stage Patients With Alzheimer's Disease, Lewy Body Dementias, and Corticobasal Syndrome.

Objective: To compare gray matter (GM) and white matter (WM) changes in patients with Alzheimer's disease (AD), Lewy body dementias (LBD), corticobasal syndrome (CBS), and healthy controls (HC).

Methods: Surface-based morphometry (SBM) was assessed on 3D T1-weighted images using FreeSurfer image analysis and WM microstructure was studied using Tract-Based Spatial Statistics (TBSS) in 12 AD, 15 LBD, 10 CBS patients, and 10 HC.

Results: Patients with AD, compared with HC, exhibited reduced cortical surface area and volume in the superior frontal, middle frontal, and medial orbitofrontal cortex. In TBSS, AD patients, compared with HC and LBD, displayed decreased fractional anisotropy, axial diffusivity, and increased radial diffusivity in all major WM tracts. Other comparisons between the groups yielded no differences, either in the SBM or the TBSS analysis.

Conclusions: The results indicate significant early structural changes in the GM of the frontal lobe, along with WM alterations early in AD patients.

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来源期刊

Journal of Geriatric Psychiatry and Neurology 医学-精神病学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Geriatric Psychiatry and Neurology (JGP) brings together original research, clinical reviews, and timely case reports on neuropsychiatric care of aging patients, including age-related biologic, neurologic, and psychiatric illnesses; psychosocial problems; forensic issues; and family care. The journal offers the latest peer-reviewed information on cognitive, mood, anxiety, addictive, and sleep disorders in older patients, as well as tested diagnostic tools and therapies.