基于细胞的再生牙髓疗法在成熟牙自体移植后的可行性和效果:病例报告。

IF 3.5 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Noriaki Yoshihashi
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引用次数: 0

摘要

自体牙移植(ATT)具有很多优点,但成功率取决于牙槽窝的形成、供体牙的操作和牙髓治疗等因素。ATT后成熟牙齿的根管治疗仍然具有挑战性。基于细胞的再生根管疗法(RET)有望再生成熟牙齿的牙髓-牙本质复合体。然而,该疗法在 ATT 后牙齿中的应用尚未得到探索。本病例报告展示了以细胞为基础的 RET 在一颗 ATT 后牙齿中的可行性和结果。一名 37 岁的男性因上颌左侧第一磨牙缺失接受了 ATT 治疗。上颌右侧第三磨牙作为供体牙,用手术导板移植。ATT 两周后开始进行根管治疗,11 周后确认未检测到残留细菌和真菌。ATT 17 周后,从上颌左侧第三磨牙中分离出的牙髓干细胞(DPSCs)被移植到根管中。ATT 牙齿在 1 周后对电髓测试做出了积极反应。供体牙齿的大部分牙周韧带缺失,ATT牙齿最初表现出类似强直的症状,但在RET 28周后恢复了正常的活动度。锥形束计算机断层扫描(CBCT)成像结果显示,52 周后牙周韧带间隙和硬膜存在,牙根没有吸收和强直。磁共振成像(MRI)显示,60 周后再生组织的信号强度与正常牙髓相当。本病例报告表明,DPSCs 能有效再生牙髓和牙周韧带,从而有可能防止 ATT 后牙齿的牙根吸收和强直。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Feasibility and Outcomes of Cell-Based Regenerative Endodontic Therapy in Post-Autogenous Transplantation of a Mature Tooth: A Case Report.

Autogenous tooth transplantation (ATT) offers advantages; however, success rates depend on factors like socket formation, donor tooth manipulation, and endodontic treatment. Root canal treatment in a mature post-ATT tooth remains challenging. Cell-based regenerative endodontic therapy (RET) shows promise for regenerating the pulp-dentin complex in mature teeth. However, its application in a post-ATT tooth is unexplored. This case report demonstrates the feasibility and outcomes of cell-based RET in a post-ATT tooth. A 37-year-old male underwent ATT for a missing maxillary left first molar. The maxillary right third molar served as the donor tooth, and transplanted with surgical guides. Root canal treatment began two weeks after ATT, confirming no detectable residual bacteria and fungi after 11 weeks. Dental pulp stem cells (DPSCs) isolated from the maxillary left third molar were transplanted into the root canal 17 weeks after ATT. The ATT tooth responded positively to the electric pulp test after 1 week. Most of the periodontal ligament of the donor tooth was absent, and the ATT tooth initially showed ankylosis-like signs but regained normal mobility after 28 weeks after RET. Cone-beam computed tomography (CBCT) imaging showed successful outcomes with the presence of the periodontal ligament space and lamina dura, and without root resorption and ankylosis after 52 weeks. Magnetic resonance imaging (MRI) revealed signal intensity of the regenerated tissue comparable to normal pulp after 60 weeks. This case report suggests the effectiveness of DPSCs in regenerating dental pulp and periodontal ligament, potentially preventing root resorption and ankylosis in the post-ATT tooth.

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来源期刊
Journal of endodontics
Journal of endodontics 医学-牙科与口腔外科
CiteScore
8.80
自引率
9.50%
发文量
224
审稿时长
42 days
期刊介绍: The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.
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