可持续释放臭氧的自愈合粘合水凝胶：增强抗菌性能，改善伤口愈合。

IF 10.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2024-11-20 DOI:10.1016/j.jconrel.2024.10.053

Shanbo Ma , Conghui Han , Xi Chen , Long Li , Xushuai Chen , Wei Zhang , Jin Wang , Fu Han , Luke Yan , Xiaopeng Shi

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引用次数: 0

摘要

抗菌水凝胶因其潜在的治疗用途而备受关注。臭氧（O₃）具有抗菌、消炎、免疫调节和抗缺氧等特性，而且其残留影响极小。然而，由于臭氧的溶解度低、寿命短，开发持续释放 O₃ 的抗菌水凝胶一直面临挑战。我们提出了一种臭氧载荷乳液水凝胶（orozonegel），它将臭氧油包裹在纳米粘土-聚（甲基丙烯酰氧乙基磺基甜菜碱）超分子网络中。这种具有粘合性、自愈合的臭氧凝胶可实现高臭氧负荷（91.3 毫摩尔/千克），并在 36 小时内释放臭氧和活性氧（ROS）。它具有广泛的抗菌和消炎作用，可促进伤口愈合。臭氧凝胶的显著特性表明它在先进生物医学应用方面具有巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Self-healing adhesive hydrogels for sustained ozone release: Enhanced antibacterial properties and improved wound healing

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Self-healing adhesive hydrogels for sustained ozone release: Enhanced antibacterial properties and improved wound healing

Antibacterial hydrogels have generated significant interest for their potential therapeutic applications. Ozone (O₃) is recognized for its antibacterial, anti-inflammatory, immunomodulatory, and anti-hypoxic properties, along with its minimal residual impact. However, the development of sustained O₃-release antibacterial hydrogels has been challenging due to the low solubility and short lifespan of ozone. We present an ozone-loaded emulsion hydrogel (ozonegel), which encapsulates ozonized oil within a nanoclay-poly(methacryloxyethyl sulfobetaine) supramolecular network. This adhesive, self-healing ozonegel achieves high ozone loading (91.3 mmol/kg) and releases O₃ and reactive oxygen species (ROS) over 36 h. It demonstrates broad antibacterial and anti-inflammatory effects, promoting wound healing. The remarkable properties of ozonegels suggest significant potential for advanced biomedical applications.

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.