CT 灌注得出的相对脑血量 < 42 % 与前循环大血管闭塞性卒中患者出院时功能预后不良呈负相关。

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neuroscience Pub Date : 2024-11-13 DOI:10.1016/j.jocn.2024.110907

Dhairya A. Lakhani , Aneri B. Balar , Vaibhav Vagal , Hamza Salim , Janet Mei , Manisha Koneru , Sijin Wen , Burak Berksu Ozkara , Hanzhang Lu , Richard Wang , Risheng Xu , Mehreen Nabi , Ishan Mazumdar , Andrew Cho , Kevin Chen , Sadra Sepehri , Francis Deng , Nathan Hyson , Victor Urrutia , Licia P. Luna , Vivek S. Yedavalli

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引用次数: 0

摘要

背景和目的：最近的研究表明，rCBV 的 CT 灌注（CTP）参数材料和方法：这项回顾性研究分析了 CT 血管造影确诊闭塞的患者，这些患者在 2017 年 1 月 9 日至 2023 年 1 月 10 日期间也接受了 CT 灌注。统计检验（Student's T、Mann-Whitney U和Chi-Square）用于评估差异。进行单变量和多变量逻辑回归分析，以评估 rCBV 的相关性结果：共有 268 名患者[中位年龄：68 岁（IQR：59-77），56.3% 为女性]符合纳入标准。其中，85 名患者（31.7%）接受了静脉溶栓治疗（IVT），221 名患者（82.5%）接受了机械血栓切除术（MT）。在对各种变量进行调整后，逻辑回归分析表明，rCBV 与血栓溶解率的关系非常密切：rCBV

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CT perfusion derived relative cerebral blood volume < 42 % is negatively associated with poor functional outcomes at discharge in anterior circulation large vessel occlusion stroke

Background and aim

Recent studies have shown that the CT Perfusion (CTP) parameter of rCBV < 42 % lesion volume can predict 90-day functional outcomes in stroke patients. However, its correlation with discharge outcomes, including functional dependence, has not been investigated. Our study aims to evaluate the relationship between rCBV < 42 % and poor functional outcomes at discharge, defined as a modified Rankin score (mRS) of 3 or higher.

Materials and methods

This retrospective study analyzed patients with confirmed occlusion on CT angiography, who also received CT perfusion between 9/1/2017 and 10/01/2023. Statistical tests (Student’s T, Mann-Whitney U, and Chi-Square) were used to assess differences. Univariable and multivariable logistic regression analyses were performed to evaluate the associations of rCBV < 42 % with discharge mRS. A p-value ≤ 0.05 was considered significant.

Results

A total of 268 patients [median age: 68 years (IQR: 59–77), 56.3 % female] met the inclusion criteria. Among them, 85 patients (31.7 %) received intravenous thrombolysis (IVT), and 221 patients (82.5 %) underwent mechanical thrombectomy (MT). After adjusting for various variables, logistic regression analysis indicated that rCBV < 42 % lesion volume was associated with poor functional outcomes at discharge (aOR = 0.97, p < 0.05). T.

Conclusion

The rCBV < 42 % could be a valuable tool in prognosticating AIS-LVO patients.

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来源期刊

Journal of Clinical Neuroscience 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

402

审稿时长

40 days

期刊介绍： This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.