来自非洲菊的两种新苷和一种新黄酮。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-11-09 DOI:10.1080/10286020.2024.2420613

Yu-Shuang Wen, Li Jiang, Yang Wang, Ying-Jie Xu, Chun-Hua Liu, Yong Huang, Xue Ma, Yong-Jun Li

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引用次数: 0

摘要

从非洲菊 50%的乙醇提取物中分离出了三种新化合物，包括两种苷类化合物，命名为非洲菊苷 E/G (1/2)，以及一种黄酮类化合物，命名为非洲菊苷 G (3)。根据 HR-ESI-MS、IR、UV 和 NMR 光谱数据阐明了它们的结构，并通过 ECD 光谱确定了 1 和 3 的绝对构型。测试了三种化合物对 RAW 264.7 细胞中 LPS 诱导的 NO 生成的抑制作用。它们表现出不同程度的抑制活性，抑制率分别为 40.55 ± 1.65%、70.13 ± 0.55%、56.74 ± 1.15%。

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Two new glycosides and a new flavone from Gerbera delavayi.

Three new compounds, including two glycosides, named gerbelavinsides E/G (1/2), and a flavone, named gerbelavin G (3), were isolated from 50% ethanol extract of Gerbera delavayi. Their structures were elucidated based on HR-ESI-MS, IR, UV and NMR spectral data, and the absolute configurations of 1 and 3 were determined by ECD spectra. Three compounds were tested for their inhibition effect against LPS-induced NO production in RAW 264.7 cells. They exhibited different degrees of inhibition activities with rates of 40.55 ± 1.65%, 70.13 ± 0.55%, 56.74 ± 1.15%, respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.