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引用次数: 0
摘要
这篇综述文章总结并评论了2022年1月至2024年9月期间发表的有关2型免疫的机理研究。2型免疫的特点是产生IL4、IL5、IL9和IL13，主要在过敏性疾病中发挥有害作用，在蠕虫感染中发挥保护作用。2 型免疫的其他功能包括抵御毒液和毒素、伤口愈合、组织重塑、再生和新陈代谢平衡。这篇综述文章讨论了有关 2 型免疫的特定细胞和体液因子（包括第 2 组先天淋巴细胞 (ILC2s)、CD4 T 细胞、肥大细胞、外周神经元和 IgE）调节这些过程和疾病状态的新发现。文章还介绍了有关环境暴露和宿主对这些因子和细胞的调控的新发现。此外，文章还讨论了最近开发的一些遗传小鼠模型，它们有可能加速该领域的发展。最后，文章评论了新发现对临床医学（包括药物开发）的意义。
This review article summarizes and comments on the mechanistic work on type 2 immunity published between January 2022 and September 2024. Type 2 immunity is characterized by the production of IL4, IL5, IL9 and IL13, and primarily known for its detrimental roles in allergic diseases and protective roles in helminth infections. Other functions of type 2 immunity include protection against venoms and toxins, wound healing, tissue remodeling, regeneration and metabolic homeostasis. This review article discusses novel findings on regulation of these processes and disease states by select cells and humoral factors of type 2 immunity, including group 2 innate lymphoid cells (ILC2s), CD4 T cells, mast cells, peripheral neurons and IgE. The article also describes novel discoveries on regulation of these factors and cells by environmental exposures and the host. Further, the article discusses select genetic mouse models that were developed recently and have the potential to accelerate the field. Finally, the article comments on the significance of novel discoveries to clinical medicine, including drug development.
期刊介绍：
The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.
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