肾缺血再灌注损伤中的间充质干细胞衍生外泌体：一种新的治疗策略。

IF 1.8 4区医学 Q3 UROLOGY & NEPHROLOGY

International Urology and Nephrology Pub Date : 2024-11-09 DOI:10.1007/s11255-024-04258-4

Bo Zhao, Zhenwang Zhang, Xiying Guo, Xiufen Liu, Min Lei, Shuang Guo, Qing Yao, Feixue Zhang, Tie Peng, Aimei Liu, Botao Jiang, Dan Zhu

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引用次数: 0

摘要

肾缺血再灌注损伤（RIRI）是一种严重的肾脏疾病，会因血流不足而造成重大损害。这种损伤导致氧化应激和炎症，可引起急性肾小管坏死和肾衰竭。干细胞衍生的外泌体是干细胞释放的小囊泡，已显示出治疗RIRI的前景。间充质干细胞（MSCs）已被用于缓解RIRI，其外泌体被发现在修复受损组织方面发挥着重要作用。这篇综述探讨了间充质干细胞不同来源的外泌体在RIRI中的关键作用、间充质干细胞衍生的外泌体在治疗这种疾病中的潜力以及未来的研究方向。

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Mesenchymal stem cell-derived exosomes in renal ischemia-reperfusion injury: a new therapeutic strategy.

Renal ischemia-reperfusion injury (RIRI) is a serious kidney condition that causes significant damage due to lack of blood flow. This injury leads to oxidative stress and inflammation, which can cause acute tubular necrosis and kidney failure. Stem cell-derived exosomes, small vesicles released by stem cells, have shown promise in treating RIRI. Mesenchymal stem cells (MSCs) have been used to mitigate RIRI, and their exosomes have been found to play a crucial role in repairing damaged tissues. This review explores the key roles of exosomes from different sources of MSCs in RIRI, the potential of MSC-derived exosomes in treating this disease, and future research directions.

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来源期刊

International Urology and Nephrology 医学-泌尿学与肾脏学

CiteScore

3.40

自引率

5.00%

发文量

329

审稿时长

1.7 months

期刊介绍： International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.