Idoia Bilbao, Iñigo Pineda Abel de la Cruz, Francisco de Asís Carmona-Torre, Mariano Rodríguez-Mateos, José Ramón Yuste Ara, Jose L Del Pozo
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Use of echinocandins combined with clindamycin in Pneumocystis pneumonia: a case series of 14 patients.
Background: Pneumocystis jirovecii pneumonia (PcP) is an opportunistic infection for which the standard of care is co-trimoxazole. However, safety concerns and intolerance may compromise its utility.
Objectives: To evaluate the safety and efficacy of the combination of echinocandins and clindamycin to treat PcP.
Patients and methods: We investigated 14 patients treated with a co-trimoxazole-free combined regimen that included echinocandins and clindamycin.
Results: Clinical cure was achieved in 8 out of 14 patients, while 5 had a fatal outcome due to their primary disease; however, only one patient died due to PcP.
Conclusions: Echinocandin and clindamycin may be a safe and effective alternative treatment for patients who cannot be given co-trimoxazole for PcP.
期刊介绍：
The Journal publishes articles that further knowledge and advance the science and application of antimicrobial chemotherapy with antibiotics and antifungal, antiviral and antiprotozoal agents. The Journal publishes primarily in human medicine, and articles in veterinary medicine likely to have an impact on global health.
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