奥罗普切病毒感染:不同的临床结果以及全球对垂直传播和致命病例的新关注。

IF 4.8 2区 医学 Q1 INFECTIOUS DISEASES
Giancarlo Ceccarelli , Francesco Branda , Fabio Scarpa , Massimo Ciccozzi , Luiz Carlos Junior Alcantara , Marta Giovanetti
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引用次数: 0

摘要

奥罗普切病毒(OROV)是一种 Peribunyaviridae 科病毒,已成为一种严重的虫媒病毒威胁,尤其是在南美洲和中美洲。传统上,奥罗普切病毒会引起轻微的发热性疾病,但最近爆发的疫情显示出严重的临床后果,包括无菌性脑膜炎、脑炎,以及最近导致先天性畸形和死亡的垂直传播。环境变化,包括森林砍伐和气候变化,扩大了病毒的地理分布范围,如巴西,截至 2024 年 8 月报告的病例超过 8000 例,而 2023 年报告的病例不到 831 例。垂直传播首次得到证实,出现了胎儿死亡和先天畸形病例,如小头畸形和胼胝体发育不全,这与 2015-2016 年爆发的寨卡病毒相似。尽管这些趋势令人震惊,但人们对胎盘传播、母体免疫和胎儿易感性的关键机制仍然知之甚少。这一观点突出表明,迫切需要采取协调一致的全球应对措施,重点是加强对新疫区的监测、病媒控制策略,以及研究导致严重临床结果的因素。加强全球努力对于减轻 OROV 带来的公共卫生威胁至关重要,特别是考虑到它有可能进一步扩大地域范围并出现严重的临床表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oropouche virus infection: Differential clinical outcomes and emerging global concerns of vertical transmission and fatal cases
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来源期刊
CiteScore
18.90
自引率
2.40%
发文量
1020
审稿时长
30 days
期刊介绍: International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.
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