PADI4 基因多态性与类风湿关节炎易感性的关系：来自 24 项病例对照研究的证据。

IF 2.3 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2024-11-09 DOI:10.1111/iji.12701

Mohammad Karimian, Fatemeh Zahra Mohammadzadeh

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Moreover, rs11203366 (G vs. A: OR = 1.46, 95% CI = 1.19-1.78, p = 0.0002, GG vs. AG + AA: OR = 1.42, 95% CI = 1.01-2.01, p = 0.043; GG + AG vs. AA: OR = 2.03, 95% CI = 1.45-2.86, p = 0.00004; GG vs. AA: OR = 2.29, 95% CI = 1.49-3.51, p = 0.0002; AG vs. AA: OR = 1.93, 95% CI = 1.35-2.76, p = 0.0003) and rs11203367 (T vs. C: OR = 1.50, 95% CI = 1.23-1.83, p = 0.00007; TT vs. CT + CC: OR = 1.56, 95% CI = 1.12-2.18, p = 0.009; TT + CT vs. CC: OR = 2.02, 95% CI = 1.43-2.84, p = 0.00007, TT vs. CC: OR = 2.43, 95% CI = 1.59-3.71, p = 0.0004; CT vs. CC: OR = 1.86, 95% CI = 1.30-2.68, p = 0.0007) had an impact in the Latino population. Bioinformatics tools showed the effect of these polymorphisms on gene function. These findings suggest that rs11203366, rs11203367, rs874881 and rs1748033 polymorphisms may be genetic risk factors for RA. 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引用次数: 0

摘要

本研究旨在通过荟萃分析和生物信息学方法研究 4 型精氨酸脱氨酶（PADI4）基因 rs11203366、rs11203367、rs874881、rs2240340 和 rs1748033 多态性与类风湿性关节炎（RA）发病风险的关联。数据收集自知名文章，并进行了定量分析，随后使用一些生物信息学工具进行了硅分析。结果显示，拉丁裔的 rs874881 多态性（G vs. C：OR = 1.35，95% CI = 1.11-1.65，p = 0.003；GG + CG vs. CC：OR = 2.02，95% CI = 1.41-2.89，p = 0.0001; CG vs. CC + GG: OR = 1.38, 95% CI = 1.04-1.83, p = 0.027; GG vs. CC: OR = 2.09, 95% CI = 1.35-3.23, p = 0.001; CG vs. CC: OR = 1.98, 95% CI = 1.36-2.87, p = 0.00033）和高加索人群中的 rs1748033（T vs. C：OR = 1.25，95% CI = 1.07-1.45，p = 0.005；TT vs. CT + CC：OR = 1.34，95% CI = 1.09-1.64，p = 0.005，TT + CT vs. CC：OR = 1.26，95% CI = 1.09-1.44，p = 0.001；TT vs. CC：OR = 1.59，95% CI = 1.13-2.23，p = 0.007；CT vs. CC：OR = 1.20，95% CI：1.04-1.39，p = 0.015）与 RA 风险增加相关。此外，rs11203366（G vs. A：OR = 1.46，95% CI = 1.19-1.78，p = 0.0002；GG vs. AG + AA：OR = 1.42，95% CI = 1.01-2.01，p = 0.043；GG + AG vs. AA：OR = 2.03，95% CI = 1.45-2.86，p = 0.00004；GG vs. AA：OR = 2.29，95% CI = 1.49-3.51，p = 0.0002；AG vs. AA：OR = 1.93，95% CI = 1.35-2.76，p = 0.0003）和 rs11203367（T vs. C：OR = 1.50，95% CI = 1.45-2.86，p = 0.00004）。C：OR = 1.50，95% CI = 1.23-1.83，p = 0.00007；TT vs. CT + CC：OR = 1.56，95% CI = 1.12-2.18，p = 0.009；TT + CT vs. CC：OR = 2.02，95% CI = 1.43-2.84，p = 0.00007, TT vs. CC: OR = 2.43, 95% CI = 1.59-3.71, p = 0.0004; CT vs. CC: OR = 1.86, 95% CI = 1.30-2.68, p = 0.0007）对拉丁裔人群有影响。生物信息学工具显示了这些多态性对基因功能的影响。这些发现表明，rs11203366、rs11203367、rs874881 和 rs1748033 多态性可能是 RA 的遗传风险因素。此外，不同人群之间的差异表明，种族可能在这些多态性对 RA 风险的影响中扮演重要角色。

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Association of PADI4 Gene Polymorphisms With Susceptibility to Rheumatoid Arthritis: Evidence From 24 Case-Control Studies.

This study aims to investigate the association of rs11203366, rs11203367, rs874881, rs2240340 and rs1748033 polymorphisms of protein-arginine deiminase type 4 (PADI4) gene with the risk of rheumatoid arthritis (RA) through a meta-analysis that was followed with a bioinformatics approach. The data were collected from reputable articles and underwent quantitative analysis, followed by in silico analysis using some bioinformatics tools. The results showed that rs874881 polymorphism in Latino (G vs. C: OR = 1.35, 95% CI = 1.11-1.65, p = 0.003; GG + CG vs. CC: OR = 2.02, 95% CI = 1.41-2.89, p = 0.0001; CG vs. CC + GG: OR = 1.38, 95% CI = 1.04-1.83, p = 0.027; GG vs. CC: OR = 2.09, 95% CI = 1.35-3.23, p = 0.001; CG vs. CC: OR = 1.98, 95% CI = 1.36-2.87, p = 0.00033) and rs1748033 in Caucasian population (T vs. C: OR = 1.25, 95% CI = 1.07-1.45, p = 0.005; TT vs. CT + CC: OR = 1.34, 95% CI = 1.09-1.64, p = 0.005, TT + CT vs. CC: OR = 1.26, 95% CI = 1.09-1.44, p = 0.001; TT vs. CC: OR = 1.59, 95% CI = 1.13-2.23, p = 0.007; CT vs. CC: OR = 1.20, 95% CI: 1.04-1.39, p = 0.015) are associated with increased risk of RA. Moreover, rs11203366 (G vs. A: OR = 1.46, 95% CI = 1.19-1.78, p = 0.0002, GG vs. AG + AA: OR = 1.42, 95% CI = 1.01-2.01, p = 0.043; GG + AG vs. AA: OR = 2.03, 95% CI = 1.45-2.86, p = 0.00004; GG vs. AA: OR = 2.29, 95% CI = 1.49-3.51, p = 0.0002; AG vs. AA: OR = 1.93, 95% CI = 1.35-2.76, p = 0.0003) and rs11203367 (T vs. C: OR = 1.50, 95% CI = 1.23-1.83, p = 0.00007; TT vs. CT + CC: OR = 1.56, 95% CI = 1.12-2.18, p = 0.009; TT + CT vs. CC: OR = 2.02, 95% CI = 1.43-2.84, p = 0.00007, TT vs. CC: OR = 2.43, 95% CI = 1.59-3.71, p = 0.0004; CT vs. CC: OR = 1.86, 95% CI = 1.30-2.68, p = 0.0007) had an impact in the Latino population. Bioinformatics tools showed the effect of these polymorphisms on gene function. These findings suggest that rs11203366, rs11203367, rs874881 and rs1748033 polymorphisms may be genetic risk factors for RA. Moreover, differences between populations suggest that ethnicity may play an important role in the effect of these polymorphisms on RA risk.

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.