Stephanie L Grach, Daniel V Dudenkov, Beth Pollack, DeLisa Fairweather, Chris A Aakre, Bala Munipalli, Ivana T Croghan, Michael R Mueller, Joshua D Overgaard, Katelyn A Bruno, Nerissa M Collins, Zhuo Li, Ryan T Hurt, Michal C Tal, Ravindra Ganesh, Dacre T R Knight
{"title":"多地点学术中心 Long COVID 的重叠条件。","authors":"Stephanie L Grach, Daniel V Dudenkov, Beth Pollack, DeLisa Fairweather, Chris A Aakre, Bala Munipalli, Ivana T Croghan, Michael R Mueller, Joshua D Overgaard, Katelyn A Bruno, Nerissa M Collins, Zhuo Li, Ryan T Hurt, Michal C Tal, Ravindra Ganesh, Dacre T R Knight","doi":"10.3389/fneur.2024.1482917","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Many patients experience persistent symptoms after COVID-19, a syndrome referred to as Long COVID (LC). The goal of this study was to identify novel new or worsening comorbidities self-reported in patients with LC.</p><p><strong>Methods: </strong>Patients diagnosed with LC (<i>n</i> = 732) at the Mayo Long COVID Care Clinic in Rochester, Minnesota and Jacksonville, Florida were sent questionnaires to assess the development of new or worsening comorbidities following COVID-19 compared to patients with SARS-CoV-2 that did not develop LC (controls). Both groups were also asked questions screening for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), generalized joint hypermobility (GJH) and orthostatic intolerance. 247 people with LC (33.7%) and 40 controls (50%) responded to the surveys.</p><p><strong>Results: </strong>In this study LC patients averaged 53 years of age and were predominantly White (95%) women (75%). The greatest prevalence of new or worsening comorbidities following SARS-CoV-2 infection in patients with LC vs. controls reported in this study were pain (94.4% vs. 0%, <i>p</i> < 0.001), neurological (92.4% vs. 15.4%, <i>p</i> < 0.001), sleep (82.8% vs. 5.3%, <i>p</i> < 0.001), skin (69.8% vs. 0%, <i>p</i> < 0.001), and genitourinary (60.6% vs. 25.0%, <i>p</i> = 0.029) issues. 58% of LC patients screened positive for ME/CFS vs. 0% of controls (<i>p</i> < 0.001), 27% positive for GJH compared to 10% of controls (<i>p</i> = 0.026), and a positive average score of 4.0 on orthostatic intolerance vs. 0 (<i>p</i> < 0.001). The majority of LC patients with ME/CFS were women (77%).</p><p><strong>Conclusion: </strong>We found that comorbidities across 12 surveyed categories were increased in patients following SARS-CoV-2 infection. Our data also support the overlap of LC with ME/CFS, GJH, and orthostatic intolerance. We discuss the pathophysiologic, research, and clinical implications of identifying these conditions with LC.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1482917"},"PeriodicalIF":2.7000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543549/pdf/","citationCount":"0","resultStr":"{\"title\":\"Overlapping conditions in Long COVID at a multisite academic center.\",\"authors\":\"Stephanie L Grach, Daniel V Dudenkov, Beth Pollack, DeLisa Fairweather, Chris A Aakre, Bala Munipalli, Ivana T Croghan, Michael R Mueller, Joshua D Overgaard, Katelyn A Bruno, Nerissa M Collins, Zhuo Li, Ryan T Hurt, Michal C Tal, Ravindra Ganesh, Dacre T R Knight\",\"doi\":\"10.3389/fneur.2024.1482917\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Many patients experience persistent symptoms after COVID-19, a syndrome referred to as Long COVID (LC). The goal of this study was to identify novel new or worsening comorbidities self-reported in patients with LC.</p><p><strong>Methods: </strong>Patients diagnosed with LC (<i>n</i> = 732) at the Mayo Long COVID Care Clinic in Rochester, Minnesota and Jacksonville, Florida were sent questionnaires to assess the development of new or worsening comorbidities following COVID-19 compared to patients with SARS-CoV-2 that did not develop LC (controls). Both groups were also asked questions screening for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), generalized joint hypermobility (GJH) and orthostatic intolerance. 247 people with LC (33.7%) and 40 controls (50%) responded to the surveys.</p><p><strong>Results: </strong>In this study LC patients averaged 53 years of age and were predominantly White (95%) women (75%). The greatest prevalence of new or worsening comorbidities following SARS-CoV-2 infection in patients with LC vs. controls reported in this study were pain (94.4% vs. 0%, <i>p</i> < 0.001), neurological (92.4% vs. 15.4%, <i>p</i> < 0.001), sleep (82.8% vs. 5.3%, <i>p</i> < 0.001), skin (69.8% vs. 0%, <i>p</i> < 0.001), and genitourinary (60.6% vs. 25.0%, <i>p</i> = 0.029) issues. 58% of LC patients screened positive for ME/CFS vs. 0% of controls (<i>p</i> < 0.001), 27% positive for GJH compared to 10% of controls (<i>p</i> = 0.026), and a positive average score of 4.0 on orthostatic intolerance vs. 0 (<i>p</i> < 0.001). The majority of LC patients with ME/CFS were women (77%).</p><p><strong>Conclusion: </strong>We found that comorbidities across 12 surveyed categories were increased in patients following SARS-CoV-2 infection. Our data also support the overlap of LC with ME/CFS, GJH, and orthostatic intolerance. We discuss the pathophysiologic, research, and clinical implications of identifying these conditions with LC.</p>\",\"PeriodicalId\":12575,\"journal\":{\"name\":\"Frontiers in Neurology\",\"volume\":\"15 \",\"pages\":\"1482917\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543549/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fneur.2024.1482917\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fneur.2024.1482917","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Overlapping conditions in Long COVID at a multisite academic center.
Background: Many patients experience persistent symptoms after COVID-19, a syndrome referred to as Long COVID (LC). The goal of this study was to identify novel new or worsening comorbidities self-reported in patients with LC.
Methods: Patients diagnosed with LC (n = 732) at the Mayo Long COVID Care Clinic in Rochester, Minnesota and Jacksonville, Florida were sent questionnaires to assess the development of new or worsening comorbidities following COVID-19 compared to patients with SARS-CoV-2 that did not develop LC (controls). Both groups were also asked questions screening for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), generalized joint hypermobility (GJH) and orthostatic intolerance. 247 people with LC (33.7%) and 40 controls (50%) responded to the surveys.
Results: In this study LC patients averaged 53 years of age and were predominantly White (95%) women (75%). The greatest prevalence of new or worsening comorbidities following SARS-CoV-2 infection in patients with LC vs. controls reported in this study were pain (94.4% vs. 0%, p < 0.001), neurological (92.4% vs. 15.4%, p < 0.001), sleep (82.8% vs. 5.3%, p < 0.001), skin (69.8% vs. 0%, p < 0.001), and genitourinary (60.6% vs. 25.0%, p = 0.029) issues. 58% of LC patients screened positive for ME/CFS vs. 0% of controls (p < 0.001), 27% positive for GJH compared to 10% of controls (p = 0.026), and a positive average score of 4.0 on orthostatic intolerance vs. 0 (p < 0.001). The majority of LC patients with ME/CFS were women (77%).
Conclusion: We found that comorbidities across 12 surveyed categories were increased in patients following SARS-CoV-2 infection. Our data also support the overlap of LC with ME/CFS, GJH, and orthostatic intolerance. We discuss the pathophysiologic, research, and clinical implications of identifying these conditions with LC.
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The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.
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