与不育对照组相比,父母平衡易位携带者的可用胚胎率或活产率不会降低。

IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY
Kyle Nguyen Le, Marcy Maguire, Nicolás Garrido Puchalt, Laura Lidon, Alejandro Sánchez-Martínez, Jason Franasiak, Emily Osman
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引用次数: 0

摘要

目的确定与不育对照组相比,易位携带者可用囊胚的数量是否会减少:设计:回顾性队列研究:2012年1月至2022年8月期间,在一家不孕不育中心接受植入前基因检测(PGT-SR)的平衡易位携带者与接受植入前基因检测(PGT-A)的非整倍体不孕患者的年龄匹配对照周期进行比较:主要结果指标:胚胎着床率、可用胚胎着床率和活产率。次要结果指标为持续植入率、受精率、取回的卵母细胞数、分裂期 II 卵母细胞数、胚胎移植失败总数、2 个无核胚胎数和优倍体胚胎数。对男性易位携带者与对照组、女性易位携带者与对照组、罗伯逊易位携带者与互易易位携带者的结果进行了比较:共纳入993名患者的1291个取卵周期,其中255名患者为易位携带者,738名患者为对照组。在易位携带者中,30 例(11.5%)为罗伯逊型,231 例(88.5%)为互易型。携带者和对照组之间的胚泡形成率差异有统计学意义(59.5% 对 62.1%;P 值 = 0.01)。不过,两组之间的可用胚泡率(47.2% 对 50.0%)相当。易位携带者和对照组在取卵数(18.5 对 18.3)、2 个无核胚胎数(13.4 对 12.5)、持续植入率(71.4% 对 75.1%)或活产率(63.0% 对 66.1%)方面没有差异。男性和女性易位携带者与对照组相比,可用胚泡率或活产率均无差异。在比较罗伯逊易位携带者和互易易位携带者时,胚胎着床率、可用胚胎着床率、持续着床率和活产率均相同:结论:尽管平衡易位携带者的优倍体胚胎较少,但与对照组相比,其可用胚泡形成率或活产率并无差异,与受影响伴侣的性别或重排类型无关。根据这些研究结果,可能没有必要对胚胎移植失败进行常规核型分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parental balanced translocation carriers do not have decreased usable blastulation rates or live birth rates compared with infertile controls.

Objective: To determine whether translocation carriers have a reduced number of usable blastocysts compared with infertile controls.

Design: Retrospective cohort study.

Setting: Single infertility practice.

Patient(s): All cycles of balanced translocation carriers undergoing in vitro fertilization with preimplantation genetic testing for structural rearrangements at a single infertility center compared with an age-matched control cycles of infertile patients undergoing preimplantation genetic testing for aneuploidy from January 2012 to August 2022.

Intervention(s): Balanced translocation carriers.

Main outcome measure(s): The primary outcome measures were blastulation rate, usable blastulation rates, and live birth rate (LBR). The secondary outcome measures were sustained implantation rate, fertilization rate, number of oocytes retrieved, number of metaphase II oocytes, total blastulation failure, number of 2-pronuclear embryos, and number of euploid embryos. Outcome measures were compared between male translocation carriers and controls, female translocation carriers and controls, and Robertsonian and reciprocal translocation carriers.

Result(s): A total of 1,291 retrieval cycles from 993 patients were included, of whom 255 patients were translocation carriers, whereas 738 were controls. Of those with translocations, 30 (11.5%) were Robertsonian carriers, and 231 (88.5%) were reciprocal carriers. There was a statistically significant difference in the blastulation rate between carriers and controls (59.5% vs. 62.1%). However, usable blastulation rates (47.2% vs. 50.0%) were equivalent between groups. There were no differences in the number of oocytes retrieved (18.5 vs. 18.3), number of 2-pronuclear embryos (13.4 vs. 12.5), sustained implantation rate (71.9% vs. 75.1%), or LBR (63.3% vs. 66.1%) between translocation carriers and controls. In both male and female translocation carriers vs. controls, there were no differences in usable blastulation rates or LBRs. When comparing Robertsonian with reciprocal translocation carriers, the rates of blastulation, usable blastulation, sustained implantation, and live birth were equivalent.

Conclusion(s): Despite fewer euploid embryos, there were no differences in the rates of usable blastulation or live birth in balanced translocation carriers, regardless of sex of affected partner or type of rearrangement, compared with controls. Routine karyotyping for blastulation failure may not be necessary on the basis of these findings.

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来源期刊
Fertility and sterility
Fertility and sterility 医学-妇产科学
CiteScore
11.30
自引率
6.00%
发文量
1446
审稿时长
31 days
期刊介绍: Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.
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